Vitamin D attenuates hyperoxia-induced lung injury through downregulation of Toll-like receptor 4

被引：44

作者：

Yao, Li ^{[1
]}

Shi, Yongyan ^{[1
]}

Zhao, Xinyi ^{[1
]}

Hou, Ana ^{[1
]}

Xing, Yujiao ^{[1
]}

Fu, Jianhua ^{[1
]}

Xue, Xindong ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Pediat, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2017年 / 39卷 / 06期

基金：

中国国家自然科学基金;

关键词：

vitamin D; hyperoxia-induced lung injury; Toll-like receptor 4; apoptosis; bronchopulmonary dysplasia; NEWBORN RATS; BRONCHOPULMONARY DYSPLASIA; INDUCED COLITIS; ACTIVATION; INFLAMMATION; APOPTOSIS; PATHWAY; CELLS; MODULATION; D-3;

D O I：

10.3892/ijmm.2017.2961

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

With considerable morbidity and mortality, bronchopulmonary dysplasia (BPD) is a focus of attention in neonatology. Hyperoxia-induced lung injury has long been used as a model of BPD. Among all the signaling pathways involved, Toll-like receptor 4 (TLR4) has been demonstrated to play an important role, and is known to be regulated by vitamin D. This study aimed at elucidating the effect of vitamin D on hyperoxia-induced lung injury and the role of TLR4 in the process. Vitamin D was administered to hyperoxia-treated neonatal rats to investigate changes in the morphology of lungs and expression of pro-inflammatory cytokines, apoptotic proteins and TLR4. Vitamin D attenuated hyperoxia-induced lung injury by protecting the integrity of the lung structure, decreasing extracellular matrix deposition and inhibiting inflammation. The upregulation of TLR4 by hyperoxia was ameliorated by vitamin D and apoptosis was reduced. Vitamin D administration antagonized the activation of TLR4 and therefore alleviated inflammation, reduced apoptosis and preserved lung structure.

引用

页码：1403 / 1408

页数：6

共 28 条

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