Amino acid esters and amides for reductive amination of mucochloric acid:: Synthesis of novel γ-lactams, short peptides and antiseizure agent levetiracetam (Keppra®)

被引：39
作者：
Das Sarma, Koushik [1 ]
Zhang, Ji [1 ]
Huang, Yun [1 ]
Davidson, James G. [1 ]
机构：
[1] Pfizer Inc, Ann Arbor Labs, Res API, Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 16期
关键词：
mucochloric acid; reductive amination; gamma-lactam; short peptides; levetiracetam;
D O I：
10.1002/ejoc.200600153
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple methodology utilizing mucochloric acid and different alpha- and beta-amino acid esters, amides and short peptides for the synthesis of novel gamma-lactam and gamma-lactam-based short peptides was developed. The synthesis of an antiseizure agent, Levetiracetam (Keppra (R)) was demonstrated. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
引用
收藏
页码：3730 / 3737
页数：8
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