Risk of death from cardiovascular disease following breast cancer in Southeast Asia: a prospective cohort study

被引:10
作者
Gernaat, S. A. M. [1 ]
Ho, P. J. [2 ]
Rijnberg, N. [3 ]
Lee, S. C. [4 ]
Lim, S. H. [5 ]
Yap, Y. S. [6 ]
Grobbee, D. E. [1 ]
Hartman, M. [7 ]
Verkooijen, H. M. [8 ]
机构
[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, NL-3584 CX Utrecht, Netherlands
[2] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
[3] Acad Med Ctr, Div Internal Med, NL-1105 AZ Amsterdam, Netherlands
[4] Natl Univ Hlth Syst, Natl Univ Canc Inst, Dept Hematol Oncol, Singapore 119074, Singapore
[5] KK Womens & Childrens Hosp, KK Breast Dept, Singapore 229899, Singapore
[6] Natl Canc Ctr Singapore, Div Med Oncol, Singapore 169610, Singapore
[7] Natl Univ Singapore Hosp, Dept Surg, Singapore 119074, Singapore
[8] Univ Med Ctr Utrecht, Imaging Div, NL-3584 CX Utrecht, Netherlands
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
关键词
ACUTE MYOCARDIAL-INFARCTION; HEART-DISEASE; MORTALITY; WOMEN; INDIANS; CHINESE; MALAYS; LIPOPROTEIN(A); RADIOTHERAPY; SINGAPORE;
D O I
10.1038/s41598-017-01540-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Breast cancer incidence and survival is high in Southeast Asia. As such, many women diagnosed with breast cancer are at risk of dying of other causes. Given the increased risk of cardiotoxicity induced by breast cancer treatments, it is important to identify patients at high risk of cardiovascular disease (CVD) mortality. The aim of this study was to investigate if this risk varies by age and ethnicity. Patient details were obtained from 5,868 Chinese, Malay, and Indian women diagnosed with in situ or non-metastasized invasive breast cancer at the National University Hospital of Singapore and KK Women's and Children's Hospital in Singapore. Death causes were obtained from the National Registry of Births and Deaths. Flexible parametric survival models estimated CVD mortality rates and hazard ratios. During a median follow-up of six years, 1,010 deaths occurred of which 6.8% were due to CVD. CVD mortality rates of older women peaked within the first year following diagnosis and increased over time since diagnosis. Indian had more than double the risk of CVD mortality than Chinese, independent of age at diagnosis and stage. Taking ethnicity and age into account may promote CVD risk stratification and management in (Southeast Asian) women with breast cancer.
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页数:7
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共 30 条
  • [1] Racial differences in breast cancer, cardiovascular disease, and all-cause mortality among women with ductal carcinoma in situ of the breast
    Berkman, Amy
    Cole, Bernard F.
    Ades, Philips A.
    Dickey, Samantha
    Higgins, Stephen T.
    Trentham-Dietz, Amy
    Sprague, Brian L.
    Lakoski, Susan G.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2014, 148 (02) : 407 - 413
  • [2] Ethnic Differences in Survival after Breast Cancer in South East Asia
    Bhoo-Pathy, Nirmala
    Hartman, Mikael
    Yip, Cheng-Har
    Saxena, Nakul
    Taib, Nur Aishah
    Lim, Siew-Eng
    Iau, Philip
    Adami, Hans-Olov
    Bulgiba, Awang M.
    Lee, Soo-Chin
    Verkooijen, Helena M.
    [J]. PLOS ONE, 2012, 7 (02):
  • [3] Cardiac toxicity in breast cancer survivors: Review of potential cardiac problems
    Bird, Brian R. J. Healey
    Swain, Sandra M.
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (01) : 14 - 24
  • [4] Cardiotoxic effects of tangential breast irradiation in early breast cancer patients: The role of irradiated heart volume
    Borger, Jacques H.
    Hooning, Maartje J.
    Boersma, Liesbeth J.
    Snijders-Keilholz, Antonia
    Aleman, Berthe M. P.
    Lintzen, Eelke
    Van Brussel, Sara
    Van der Toorn, Peter-Paul
    Alwhouhayb, Maitham
    Van Leeuwen, Flora E.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (04): : 1131 - 1138
  • [5] Bradshaw P. T., 2015, EPIDEMIOLOGY
  • [6] Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics
    Colzani, Edoardo
    Liljegren, Annelie
    Johansson, Anna L. V.
    Adolfsson, Jan
    Hellborg, Henrik
    Hall, Per F. L.
    Czene, Kamila
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (30) : 4014 - 4021
  • [7] Novel concepts in radiation-induced cardiovascular disease
    Cuomo, Jason R.
    Sharma, Gyanendra K.
    Conger, Preston D.
    Weintraub, Neal L.
    [J]. WORLD JOURNAL OF CARDIOLOGY, 2016, 8 (09): : 504 - 519
  • [8] General cardiovascular risk profile for use in primary care - The Framingham Heart Study
    D'Agostino, Ralph B.
    Vasan, Ramachandran S.
    Pencina, Michael J.
    Wolf, Philip A.
    Cobain, Mark
    Massaro, Joseph M.
    Kannel, William B.
    [J]. CIRCULATION, 2008, 117 (06) : 743 - 753
  • [9] A Dose-response Relationship for the Incidence of Radiation-related Heart Disease
    Darby, S. C.
    Bronnum, D.
    Correa, C.
    Ewertz, M.
    Gagliardi, G.
    Gigante, B.
    McGale, P.
    Nisbet, A.
    Taylor, C.
    Hall, P.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (03): : S49 - S50
  • [10] Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries
    Darby, SC
    McGale, P
    Taylor, CW
    Peto, R
    [J]. LANCET ONCOLOGY, 2005, 6 (08) : 557 - 565