Fibrinogen and its oxidized form induce interleukin-2 production in cultured endothelial cells of human vessels

被引：5

作者：

Azizova, OA ^{[1
]}

Maksyanina, EV ^{[1
]}

Romanov, YA ^{[1
]}

Aseichev, AV ^{[1
]}

Scheglovitova, ON ^{[1
]}

机构：

[1] Russian Minist Hlth, Inst Physicochem Med, Lab Biophys Bases Pathol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 04期

关键词：

oxidized fibrinogen; interleukin-8; culture of vascular endothelium;

D O I：

10.1023/B:BEBM.0000035129.62456.29

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oxidized fibrinogen was more potent than native fibrinogen in inducing interleukin-8 production in primary culture of human endothelial cells. The optimal concentration of oxidized fibrinogen was 3 mg/ml. The optimal time of UV irradiation was 17 min. Secretion of interleukin-8 was maximum during culturing of endothelial cells in a serum-free medium.

引用

页码：358 / 360

页数：3

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