Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans With Rheumatoid Arthritis

被引：15

作者：

Arya, Rector ^{[1
,2
]}

del Rincon, Inmaculada ^{[3
]}

Farook, Vidya S. ^{[1
,2
]}

Restrepo, Jose F. ^{[3
]}

Winnier, Diedre A. ^{[4
]}

Fourcaudot, Marcel J. ^{[5
]}

Battafarano, Daniel F. ^{[6
]}

de Almeida, Marcio ^{[7
,8
]}

Kumar, Satish ^{[1
,2
]}

Curran, Joanne E. ^{[7
,8
]}

Jenkinson, Christopher P. ^{[1
,2
]}

Blangero, John ^{[7
,8
]}

Duggirala, Ravindranath ^{[1
,2
]}

Escalante, Agustin ^{[3
]}

机构：

[1] Univ Texas Hlth Sci Ctr, South Texas Diabet & Obes Inst, Edinburg, TX USA

[2] Univ Texas Hlth Sci Ctr, Reg Acad Hlth Ctr, Edinburg, TX USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Rheumatol & Clin Immunol, San Antonio, TX 78229 USA

[4] Univ Hlth Syst, Res & Informat Management, San Antonio, TX USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Diabet, San Antonio, TX 78229 USA

[6] Brook Army Med Ctr, Ft Sam Houston, TX USA

[7] South Texas Diabet & Obes Inst, Brownsville, TX USA

[8] UT Brownsville, Brownsville, TX USA

来源：

GENETIC EPIDEMIOLOGY | 2015年 / 39卷 / 08期

关键词：

rheumatoid arthritis susceptibility loci; joint damage; genetic association; Mexican Americans; European Americans; GENOME-WIDE ASSOCIATION; NF-KAPPA-B; SUSCEPTIBILITY LOCI; TNF; RISK; METAANALYSIS; DESTRUCTION; PATHWAY; POLYMORPHISM; PROGRESSION;

D O I：

10.1002/gepi.21938

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Joint destruction in rheumatoid arthritis (RA) is heritable, but knowledge on specific genetic determinants of joint damage in RA is limited. We have used the Immunochip array to examine whether genetic variants influence variation in joint damage in a cohort of Mexican Americans (MA) and European Americans (EA) with RA. We studied 720 MA and 424 EA patients with RA. Joint damage was quantified using a radiograph of both hands and wrists, scored using Sharp's technique. We conducted association analyses with the transformed Sharp score and the Immunochip single nucleotide polymorphism (SNP) data using PLINK. In MAs, 15 SNPs from chromosomes 1, 5, 9, 17 and 22 associated with joint damage yielded strong p-values (p < 1 x 10(-4)). The strongest association with joint damage was observed with rs7216796, an intronic SNP located in the MAP3K14 gene, on chromosome 17 (beta +/- SE = -0.25 +/- 0.05, p = 6.23 x 10(-6)). In EAs, 28 SNPs from chromosomes 1, 4, 6, 9, and 21 showed associations with joint damage (p-value < 1 x 10-4). The best association was observed on chromosome 9 with rs59902911 (beta +/- SE = 0.86 +/- 0.17, p = 1.01 x 10(-6)), a synonymous SNP within the CARD9 gene. We also observed suggestive evidence for some loci influencing joint damage in MAs and EAs. We identified two novel independent loci (MAP3K14 and CARD9) strongly associated with joint damage in MAs and EAs and a few shared loci showing suggestive evidence for association. (C) 2015 Wiley Periodicals, Inc.

引用

页码：678 / 688

页数：11

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