PKM2: a crucial neuroprotective target against oxidative stress

被引：6
作者：
Zhou, Qionglin [1 ]
Tang, Mingzhu [2 ]
He, Lu [3 ]
Chen, Shuiping [1 ]
机构：
[1] Southern Med Univ, Shaoguan Hosp, Peoples Hosp Shaoguan 1, Dept Pharm, Shaoguan 512000, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Peoples R China
[3] Univ South China, Dept Neurosurg, Affiliated Hosp 1, Hengyang 421001, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2020年 / 52卷 / 12期
基金：
中国国家自然科学基金;
关键词：
PYRUVATE-KINASE; METABOLISM; NEURONS; M2;
D O I：
10.1093/abbs/gmaa121
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1432 / 1434
页数：3
相关论文
共 11 条
  • [1] Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
    Anastasiou, Dimitrios
    Poulogiannis, George
    Asara, John M.
    Boxer, Matthew B.
    Jiang, Jian-kang
    Shen, Min
    Bellinger, Gary
    Sasaki, Atsuo T.
    Locasale, Jason W.
    Auld, Douglas S.
    Thomas, Craig J.
    Vander Heiden, Matthew G.
    Cantley, Lewis C.
    [J]. SCIENCE, 2011, 334 (6060) : 1278 - 1283
  • [2] PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
    Azoitei, Ninel
    Becher, Alexander
    Steinestel, Konrad
    Rouhi, Arefeh
    Diepold, Kristina
    Genze, Felicitas
    Simmet, Thomas
    Seufferlein, Thomas
    [J]. MOLECULAR CANCER, 2016, 15
  • [3] NRF2 as a Therapeutic Target in Neurodegenerative Diseases
    Brandes, Mikah S.
    Gray, Nora E.
    [J]. ASN NEURO, 2020, 12
  • [4] The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    Christofk, Heather R.
    Vander Heiden, Matthew G.
    Harris, Marian H.
    Ramanathan, Arvind
    Gerszten, Robert E.
    Wei, Ru
    Fleming, Mark D.
    Schreiber, Stuart L.
    Cantley, Lewis C.
    [J]. NATURE, 2008, 452 (7184) : 230 - U74
  • [5] L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade
    Jourdain, P.
    Allaman, I.
    Rothenfusser, K.
    Fiumelli, H.
    Marquet, P.
    Magistretti, P. J.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [6] Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways
    Kim, Nam-Tae
    Lee, Dong-Sung
    Chowdhury, Anisuzzaman
    Lee, Hwan
    Cha, Byung-Yoon
    Woo, Je-Tae
    Woo, Eun Rhan
    Jang, Jun-Hyeog
    [J]. MOLECULAR MEDICINE REPORTS, 2017, 16 (02) : 1537 - 1543
  • [7] Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling
    Tauffenberger, Arnaud
    Fiumelli, Hubert
    Almustafa, Salam
    Magistretti, Pierre J.
    [J]. CELL DEATH & DISEASE, 2019, 10 (9)
  • [8] Reprogramming energetic metabolism in Alzheimer's disease
    Vallee, Alexandre
    Lecarpentier, Yves
    Guillevin, Remy
    Vallee, Jean-Noel
    [J]. LIFE SCIENCES, 2018, 193 : 141 - 152
  • [9] Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
    Wei, Yao
    Lu, Ming
    Mei, Meng
    Wang, Haoran
    Han, Zhitao
    Chen, Miaomiao
    Yao, Hang
    Song, Nanshan
    Ding, Xiao
    Ding, Jianhua
    Xiao, Ming
    Hu, Gang
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [10] Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
    Yang, Jiangyan
    Ruchti, Evelyne
    Petit, Jean-Marie
    Jourdain, Pascal
    Grenningloh, Gabriele
    Allaman, Igor
    Magistretti, Pierre J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (33) : 12228 - 12233
12