Incremental Value of Cocktail 18F-FDG and 18F-NaF PET/CT Over 18F-FDG PET/CT Alone for Characterization of Skeletal Metastases in Breast Cancer

被引:14
作者
Roop, Mohan J. [1 ]
Singh, Baljinder [1 ]
Singh, Harmandeep [1 ]
Watts, Ankit [1 ]
Kohli, Pavneet S. [2 ]
Mittal, Bhagwant R. [1 ]
Singh, Gurpreet [2 ]
机构
[1] Postgrad Inst Med Educ & Res, Dept Nucl Med, Chandigarh 160012, India
[2] Postgrad Inst Med Educ & Res, Dept Gen Surg, Chandigarh, India
关键词
F-18-FDG PET/CT; F-18-NaF PET/CT; breast cancer; cocktail PET/CT; skeletal metastases; POSITRON-EMISSION-TOMOGRAPHY; OSTEOBLASTIC BONE METASTASES; FDG-PET; SUSPECTED RECURRENCE; NODE BIOPSY; FLUORODEOXYGLUCOSE; SCINTIGRAPHY; SPECT; LUNG; F-18-FLUORIDE;
D O I
10.1097/RLU.0000000000001615
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The aim of this study was to evaluate the incremental value of cocktail F-18-FDG/F-18-NaF PET/CT over F-18-FDG PET/CT alone for detection of skeletal metastases in breast cancer patients. Methods: Seventy patients with locally advanced/recurrent breast cancer were prospectively included. All patients underwent whole-body F-18-FDG PET/CT and cocktail F-18-FDG/F-18-NaF PET/CT within a span of 1 week. Both studies were evaluated to detect presence of skeletal/marrow metastases on PET/CT images by 2 nuclear medicine physicians. Clinical and radiological correlation/follow-up was used as criterion standard. Results: Of 70 patients, 50 (71.0%) had locally advanced breast cancer, and 20 had recurrent breast cancer. On patient-wise analysis, both cocktail PET/CT and F-18-FDG PET/CT identified skeletal/marrow lesions in 23 (32.8%) of 70 patients. In 8 patients (11.4%), only cocktail PET/CT identified skeletal/marrow lesions, whereas F-18-FDG PET/CTwas negative. In the rest of the 39 patients (55.8%), no skeletal/marrow lesion was identified on both scans. Good correlation was noted between cocktail PET/CT and F-18-FDG PET/CT results (r - 0.785, P < 0.0001). Cocktail PET/CT detected lesions in significantly more number of patients than F-18-FDG PET/CT alone (P = 0.007). On lesion-wise analysis, cocktail PET/CT detected more number of lesions in 20 patients as compared with F-18-FDG-PET/CTalone. Both scans detected same number of lesions in the rest of 11 patients with positive findings. A total of 32 additional lesions were identified on cocktail PET/CT imaging as compared with F-18 PET/CT alone (P < 0.0001). Conclusions: Cocktail F-18-FDG and F-18-NaF PET/CT is superior to F-18-FDG PET/CT alone for the detection of skeletal/marrow metastases in breast cancer. It can be a better alternative to F-18-FDG PET/CT alone in facilities where both tracers are available.
引用
收藏
页码:335 / 340
页数:6
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