Association of atopic dermatitis with inflammatory bowel disease: A systematic review and meta-analysis

被引：9
作者：
Wang, Chi-Hui [1 ,2 ]
Fu, Yun [1 ]
Chi, Ching-Chi [1 ,3 ]
机构：
[1] Chang Gung Mem Hosp, Dept Dermatol, 5 Fuxing St, Taoyuan 33305, Taiwan
[2] Chang Gung Mem Hosp, Dept Dermatol, Keelung, Taiwan
[3] Chang Gung Univ, Coll Med, Taoyuan, Taiwan
来源：
DERMATOLOGICA SINICA | 2020年 / 38卷 / 03期
关键词：
Atopic dermatitis; Crohn's disease; inflammatory bowel disease; meta-analysis; ulcerative colitis; AUTOIMMUNE-DISEASES; RISK-FACTORS; ADULTS; MECHANISMS; PSORIASIS; BARRIER; ECZEMA; COMORBIDITIES; EPIDEMIOLOGY; PATHOGENESIS;
D O I：
10.4103/ds.ds_20_20
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Altered microbiota of the gastrointestinal tract have been implicated in both atopic dermatitis (AD) and inflammatory bowel disease (IBD). However, the relationship between AD and IBD has been unclear. Objectives: The objective of this study was to systemically assess the evidence on the association of AD with IBD. Methods: We conducted a systematic review and meta-analysis of observational studies on the association of AD with IBD. We searched MEDLINE, Embase, CENTRAL, Web of Science, and Airiti Library from inception to May 24, 2019, for relevant studies. The outcomes were the odds and risk of Crohn's disease (CD) and ulcerative colitis (UC) in patients with AD. Results: We included five case-control studies and one cohort study. We identified significant associations of AD with prevalent CD (odds ratio [OR]: 1.55, 95% confidence interval [CI]: 1.11-2.15) and UC (OR: 2.49, 95% CI: 1.04-5.98). One Danish cohort study found no increased risk for incident CD (hazard ratio [HR]: 0.69, 95% CI: 0.34-1.30) and UC (HR: 0.94, 95% CI: 0.61-1.43) in patients with AD. Conclusion: The current limited evidence supports an association of AD with prevalent IBD. Digestive symptoms in patients with AD, for example, chronic diarrhea and abdominal pain, shall not be overlooked, and gastroenterology counseling may be needed.
引用
收藏
页码：159 / 165
页数：7
相关论文
共 52 条
[31]  
Liberati A, 2009, BMJ-BRIT MED J, V339, DOI [10.1136/bmj.b2700, 10.1371/journal.pmed.1000097, 10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.b2535, 10.1136/bmj.i4086]
[32]   Intestinal microbiota and allergic diseases: A systematic review [J].
Melli, L. C. F. L. ;
do Carmo-Rodrigues, M. S. ;
Araujo-Filho, H. B. ;
Sole, D. ;
de Morais, M. B. .
ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2016, 44 (02) :177-188
[33]   Association between atopic dermatitis and autoimmune disorders in US adults and children: A cross-sectional study [J].
Narla, Shanthi ;
Silverberg, Jonathan I. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2019, 80 (02) :382-389
[34]   An association between ulcerative colitis and atopic dermatitis, diseases of impaired superficial barriers [J].
Niwa, Y ;
Sumi, H ;
Akamatsu, H .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (05) :999-1000
[35]   The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization [J].
Noda, Shinji ;
Suarez-Farinas, Mayte ;
Ungar, Benjamin ;
Kim, Soo Jung ;
Strong, Cristina de Guzman ;
Xu, Hui ;
Peng, Xiangyu ;
Estrada, Yeriel D. ;
Nakajima, Saeko ;
Honda, Tetsuya ;
Shin, Jung U. ;
Lee, Hemin ;
Krueger, James G. ;
Lee, Kwang-Hoon ;
Kabashima, Kenji ;
Guttman-Yassky, Emma .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 136 (05) :1254-1264
[36]   Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations [J].
O'Regan, Grainne M. ;
Campbell, Linda E. ;
Cordell, Heather J. ;
Irvine, Alan D. ;
McLean, W. H. Irwin ;
Brown, Sara J. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) :170-174
[37]   Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis [J].
Palmer, CNA ;
Irvine, AD ;
Terron-Kwiatkowski, A ;
Zhao, YW ;
Liao, HH ;
Lee, SP ;
Goudie, DR ;
Sandilands, A ;
Campbell, LE ;
Smith, FJD ;
O'Regan, GM ;
Watson, RM ;
Cecil, JE ;
Bale, SJ ;
Compton, JG ;
DiGiovanna, JJ ;
Fleckman, P ;
Lewis-Jones, S ;
Arseculeratne, G ;
Sergeant, A ;
Munro, CS ;
El Houate, B ;
McElreavey, K ;
Halkjaer, LB ;
Bisgaard, H ;
Mukhopadhyay, S ;
McLean, WHI .
NATURE GENETICS, 2006, 38 (04) :441-446
[38]   MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].
Abraham, Clara ;
Cho, Judy H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078
[39]   The Gut Microbiome as a Major Regulator of the Gut-Skin Axis [J].
Salem, Iman ;
Ramser, Amy ;
Isham, Nancy ;
Ghannoum, Mahmoud A. .
FRONTIERS IN MICROBIOLOGY, 2018, 9
[40]   Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes [J].
Schmitt, Jochen ;
Schwarz, Kristin ;
Baurecht, Hansjoerg ;
Hotze, Melanie ;
Foelster-Holst, Regina ;
Rodriguez, Elke ;
Lee, Young A. E. ;
Franke, Andre ;
Degenhardt, Frauke ;
Lieb, Wolfgang ;
Gieger, Christian ;
Kabesch, Michael ;
Noethen, Markus M. ;
Irvine, Alan D. ;
McLean, W. H. Irwin ;
Deckert, Stefanie ;
Stephan, Victoria ;
Schwarz, Peter ;
Aringer, Martin ;
Novak, Natalija ;
Weidinger, Stephan .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (01) :130-136
123456