HIV care in Central and Eastern Europe: How close are we to the target

被引:41
作者
Gokengin, Deniz [1 ]
Oprea, Cristiana [2 ]
Begovac, Josip [3 ]
Horban, Andrzej [4 ]
Zeka, Arzu Nazli [5 ]
Sedlacek, Dalibor [6 ]
Allabergan, Bayjanov [7 ]
Almamedova, Esmira A. [8 ]
Balayan, Tatevik [9 ]
Banhegyi, Denes [10 ]
Bukovinova, Pavlina [11 ]
Chkhartishvili, Nikoloz [12 ]
Damira, Alymbaeva [13 ]
Deva, Edona [14 ]
Elenkov, Ivaylo [15 ]
Gashi, Luljeta [16 ]
Gexha-Bunjaku, Dafina [16 ]
Hadciosmanovic, Vesna [17 ]
Harxhi, Arjan [18 ]
Holban, Tiberiu [19 ]
Jevtovic, Djorje [20 ]
Jilich, David [21 ,22 ]
Kowalska, Justyna [4 ]
Kuvatova, Djhamal [13 ]
Ladnaia, Natalya [23 ]
Mamatkulov, Adkhamjon [7 ]
Marjanovic, Aleksandra [24 ]
Nikolova, Maria [25 ]
Poljak, Mario [26 ]
Ruutel, Kristi [27 ]
Shunnar, Azzaden [11 ]
Stevanovic, Milena [28 ]
Trumova, Zhanna [29 ]
Yurin, Oleg [23 ]
机构
[1] Ege Univ Izmir, Fac Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey
[2] Carol Davila Univ Med & Pharm, Victor Babes Clin Hosp Infect & Trop Dis, Bucharest, Romania
[3] Univ Zagreb, Sch Med, Univ Hosp Infect Dis, Zagreb, Croatia
[4] Med Univ Warsaw, Hosp Infect Dis Warsaw, Warsaw, Poland
[5] Yunus Emre State Hosp, Eskisehir, Turkey
[6] Charles Univ Prague, Med Fac, Dept Infect & Travellers Dis, Plzen, Czech Republic
[7] Minist Publ Hlth Uzbekistan, Inst Virol, Tashkent, Uzbekistan
[8] AIDS Control Ctr, Baku, Azerbaijan
[9] Natl Ctr Dis Control & Prevent Armenia, Yerevan, Armenia
[10] Szent Laszlo Hosp, Budapest, Hungary
[11] Univ Hosp, Ctr HIV AIDS, Clin Infect Dis, Bratislava, Slovakia
[12] AIDS & Clin Immunol Res Ctr, Infect Dis, Tbilisi, Georgia
[13] Kyrgyz Russian Slavonic Univ, Dept Infect Dis, Div Med, Bishkek, Kyrgyzstan
[14] Community Dev Fund, Prishtina, Kosovo
[15] Specialized Hosp Act Treatment Infect & Parasit D, Sofia, Bulgaria
[16] Natl Inst Publ Hlth Kosovo, Prishtina, Kosovo
[17] Univ Sarajevo, Clin Ctr, Infect Dis Clin, Sarajevo, Bosnia & Herceg
[18] Univ Hosp Ctr Tirana, Fac Med, Infect Dis Dept, Tiran, Albania
[19] State Med & Pharmaceut Univ Nicolae Testemitanu, Dept Infect Dis & Med Parasitol, Kishinev, Moldova
[20] Univ Belgrade, Sch Med, Infect & Trop Dis Hosp, HIV AIDS Unit,Clin Ctr Serbia, Belgrade, Serbia
[21] Charles Univ Prague, Fac Med 1, Dept Infect & Trop Dis, Prague, Czech Republic
[22] Na Bulovce Hosp, Prague, Czech Republic
[23] Russian Fed AIDS Ctr, Cent Sci Res Inst Epidemiol Rospotrebnadzor, Moscow, Russia
[24] Inst Publ Hlth, Podgorica, Montenegro
[25] Natl Ctr Infect & Parasit Dis, Natl Reference Lab Immunol, Sofia, Bulgaria
[26] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia
[27] Natl Inst Hlth Dev, Tallinn, Estonia
[28] Clin Infect Dis & Febrile Condit, Skopje, North Macedonia
[29] Kazakh Natl Med Univ, Dept HIV Infect & Infect Control, Alma Ata, Kazakhstan
关键词
HIV care; Central Europe; Eastern Europe; 90-90-90n targets; MEN;
D O I
10.1016/j.ijid.2018.03.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: The aim of this survey was to describe the current status of HIV care in the countries of Central and Eastern Europe and to investigate how close the region is to achieving the UNAIDS 2020 target of 9090-90. Methods: In 2014, data were collected from 24 Central and Eastern European countries using a 38-item questionnaire. Results: All countries reported mandatory screening of blood and organ donors for HIV. Other groups subjected to targeted screening included people who inject drugs (PWID) (15/24, 62.5%), men who have sex with men (MSM) (14/24, 58.3%), and sex workers (12/24, 50.0%). Only 14 of the 24 countries (58.3%) screened pregnant women. The percentages of late presentation and advanced disease were 40.3% (range 14-80%) and 25.4% (range 9-50%), respectively. There was no difference between countries categorized by income or by region in terms of the percentages of persons presenting late or with advanced disease. The availability of newer antiretroviral drugs (rilpivirine, etravirine, darunavir, maraviroc, raltegravir, dolutegravir) tended to be significantly better with a higher country income status. Ten countries reported initiating antiretroviral therapy (ART) regardless of CD4+ T cell count (41.7%), five countries (20.8%) used the threshold of <500 cells/mu l, and nine countries (37.5%) used the threshold of <350cells/ mu I. Initiation of ART regardless of the CD4+ T cell count was significantly more common among highincome countries than among upper-middle-income and lower-middle-income countries (100% vs. 27.3% and 0%, respectively; p = 0.001). Drugs were provided free of charge in all countries and mostly provided by governments. There were significant discrepancies between countries regarding the follow-up of people living with HIV. Conclusions: There are major disparities in the provision of HIV care among sub-regions in Europe, which should be addressed. More attention in terms of funding, knowledge and experience sharing, and capacity building is required for the resource-limited settings of Central and Eastern Europe. The exact needs should be defined and services scaled up in order to achieve a standard level of care and provide an adequate and sustainable response to the HIV epidemic in this region. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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页码:121 / 130
页数:10
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