Casein kinase 1α: biological mechanisms and theranostic potential

被引：84
作者：
Jiang, Shaojie [1 ]
Zhang, Miaofeng [2 ]
Sun, Jihong [1 ]
Yang, Xiaoming [1 ,3 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed, Hangzhou 310009, Zhejiang, Peoples R China
[3] Univ Washington, Sch Med, Dept Radiol, Image Guided Biomol Intervent Res, Seattle, WA 98109 USA
来源：
CELL COMMUNICATION AND SIGNALING | 2018年 / 16卷
基金：
中国国家自然科学基金;
关键词：
Casein kinase 1 alpha; Wnt/beta-catenin signaling; NF-kappa B signaling; Hedgehog signaling; Autophagy; Neurodegenerative disease; Cell cycle; Host defense response; NF-KAPPA-B; INTEGRATED MOLECULAR ANALYSIS; CYCLIN-DEPENDENT KINASE-5; AMYLOID PRECURSOR PROTEIN; BETA-CATENIN ACTIVATION; GENOME-WIDE ANALYSIS; E3 UBIQUITIN LIGASE; I-ALPHA; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE;
D O I：
10.1186/s12964-018-0236-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Casein kinase 1 alpha (CK1 alpha) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1 alpha is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1 alpha, and provide an overview of existing challenges and potential opportunities for advancing theranostics.
引用
收藏
页数：24
相关论文
共 261 条
  • [1] Genetic effects on gene expression across human tissues
    Aguet, Francois
    Brown, Andrew A.
    Castel, Stephane E.
    Davis, Joe R.
    He, Yuan
    Jo, Brian
    Mohammadi, Pejman
    Park, Yoson
    Parsana, Princy
    Segre, Ayellet V.
    Strober, Benjamin J.
    Zappala, Zachary
    Cummings, Beryl B.
    Gelfand, Ellen T.
    Hadley, Kane
    Huang, Katherine H.
    Lek, Monkol
    Li, Xiao
    Nedzel, Jared L.
    Nguyen, Duyen Y.
    Noble, Michael S.
    Sullivan, Timothy J.
    Tukiainen, Taru
    MacArthur, Daniel G.
    Getz, Gad
    Management, Nih Program
    Addington, Anjene
    Guan, Ping
    Koester, Susan
    Little, A. Roger
    Lockhart, Nicole C.
    Moore, Helen M.
    Rao, Abhi
    Struewing, Jeffery P.
    Volpi, Simona
    Collection, Biospecimen
    Brigham, Lori E.
    Hasz, Richard
    Hunter, Marcus
    Johns, Christopher
    Johnson, Mark
    Kopen, Gene
    Leinweber, William F.
    Lonsdale, John T.
    McDonald, Alisa
    Mestichelli, Bernadette
    Myer, Kevin
    Roe, Bryan
    Salvatore, Michael
    Shad, Saboor
    [J]. NATURE, 2017, 550 (7675) : 204 - +
  • [2] Toll-like receptor signalling
    Akira, S
    Takeda, K
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511
  • [3] Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities
    Alappat, EC
    Feig, C
    Boyerinas, B
    Volkland, J
    Samuels, M
    Murmann, AE
    Thorburn, A
    Kidd, VJ
    Slaughter, CA
    Osborn, SL
    Winoto, A
    Tang, WJ
    Peter, ME
    [J]. MOLECULAR CELL, 2005, 19 (03) : 321 - 332
  • [4] Axin-mediated CKI phosphorylation of β-catenin at Ser 45:: a molecular switch for the Wnt pathway
    Amit, S
    Hatzubai, A
    Birman, Y
    Andersen, JS
    Ben-Shushan, E
    Mann, M
    Ben-Neriah, Y
    Alkalay, I
    [J]. GENES & DEVELOPMENT, 2002, 16 (09) : 1066 - 1076
  • [5] Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
    Anastassiadis, Theonie
    Deacon, Sean W.
    Devarajan, Karthik
    Ma, Haiching
    Peterson, Jeffrey R.
    [J]. NATURE BIOTECHNOLOGY, 2011, 29 (11) : 1039 - U117
  • [6] Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
    Anderson, John P.
    Walker, Donald E.
    Goldstein, Jason M.
    de laat, Rian
    Banducci, Kelly
    Caccavello, Russell J.
    Barbour, Robin
    Huang, Jiping
    Kling, Kristin
    Lee, Michael
    Diep, Linnea
    Keim, Pamela S.
    Shen, Xiaofeng
    Chataway, Tim
    Schlossmacher, Michael G.
    Seubert, Peter
    Schenk, Dale
    Sinha, Sukanto
    Gai, Wei Ping
    Chilcote, Tamie J.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (40) : 29739 - 29752
  • [7] Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    Apionishev, S
    Katanayeva, NM
    Marks, SA
    Kalderon, D
    Tomlinson, A
    [J]. NATURE CELL BIOLOGY, 2005, 7 (01) : 86 - +
  • [8] CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue
    Bao, Xiaomin
    Siprashvili, Zurab
    Zarnegar, Brian J.
    Shenoy, Rajani M.
    Rios, Eon J.
    Nady, Natalie
    Qu, Kun
    Mah, Angela
    Webster, Daniel E.
    Rubin, Adam J.
    Wozniak, Glenn G.
    Tao, Shiying
    Wysocka, Joanna
    Khavari, Paul A.
    [J]. DEVELOPMENTAL CELL, 2017, 43 (02) : 227 - +
  • [9] Targeting the Wnt Pathway in Synovial Sarcoma Models
    Barham, Whitney
    Frump, Andrea L.
    Sherrill, Taylor P.
    Garcia, Christina B.
    Saito-Diaz, Kenyi
    VanSaun, Michael N.
    Fingleton, Barbara
    Gleaves, Linda
    Orton, Darren
    Capecchi, Mario R.
    Blackwell, Timothy S.
    Lee, Ethan
    Yull, Fiona
    Eid, Josiane E.
    [J]. CANCER DISCOVERY, 2013, 3 (11) : 1286 - 1301
  • [10] BAZENET CE, 1990, J BIOL CHEM, V265, P7369
12345678910