Electrospinning as a powerful technique for biomedical applications: a critically selected survey

被引:117
作者
Jesus Villarreal-Gomez, Luis [1 ,2 ]
Manuel Cornejo-Bravo, Jose [2 ]
Vera-Graziano, Ricardo [3 ]
Grande, Daniel [4 ]
机构
[1] Univ Autonoma Baja California, Escuela Ciencias Ingn & Tecnol, Tijuana, Mexico
[2] Univ Autonoma Baja California, Fac Ciencias Quim & Ingn, Tijuana, Mexico
[3] Univ Nacl Autonoma Mexico, Inst Invest Mat, Mexico City 04510, DF, Mexico
[4] Univ Paris Est Creteil, Complex Polymer Syst Lab, Inst Chim & Mat Paris Est, CNRS,UMR 7182, Thiais, France
关键词
Drug delivery systems; electrospinning; natural polymers; synthetic polymers; tissue engineering scaffolds; OSTEOGENIC DIFFERENTIATION; CHITOSAN NANOFIBERS; DRUG-DELIVERY; SCAFFOLDS; NANOPARTICLES; MATS; PVA; NANOSTRUCTURES; BIOPOLYMERS; DEGRADATION;
D O I
10.1080/09205063.2015.1116885
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Nowadays, electrospinning has become one of the most versatile, easy, and cost-effective techniques to engineer advanced materials used for many applications, especially in the biomedical and environmental areas. Like the numerous patents around the world, the increasing number of papers witnesses the huge potential of this simple process, and many companies have been emerged during the last years to exploit its innumerable applications. This article presents a critically selected overview of polymers that can be used to produce nanofibers, along with the biomedical applications of the resulting electrospun scaffolds. We have focused on about seven natural and synthetic polymers, but many more can be found in the literature, either as their pristine state or as composites with ceramics, metals, and other polymers. The description of some strategies for nanofiber production, and the characterization used to evaluate their optimization, has been discussed. Finally, several polymers have been recognized as highlights for future work.
引用
收藏
页码:157 / 176
页数:20
相关论文
共 76 条
[1]   Use of electrospinning technique for biomedical applications [J].
Agarwal, Seema ;
Wendorff, Joachim H. ;
Greiner, Andreas .
POLYMER, 2008, 49 (26) :5603-5621
[2]   Fibrin: A versatile scaffold for tissue engineering applications [J].
Ahmed, Tamer A. E. ;
Dare, Emma V. ;
Hincke, Max .
TISSUE ENGINEERING PART B-REVIEWS, 2008, 14 (02) :199-215
[3]   Effects of sterilisation method on surface topography and in-vitro cell behaviour of electrostatically spun scaffolds [J].
Andrews, Kirstie D. ;
Hunt, John A. ;
Black, Richard A. .
BIOMATERIALS, 2007, 28 (06) :1014-1026
[4]  
Lozano-Alvarez JA, 2009, J MEX CHEM SOC, V53, P59
[5]   Development and properties of polycaprolactone/hydroxyapatite composite biomaterials [J].
Azevedo, MC ;
Reis, RL ;
Claase, BM ;
Grijpma, DW ;
Feijen, J .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2003, 14 (02) :103-107
[6]   Chitosan-based drug delivery systems [J].
Bernkop-Schnuerch, Andreas ;
Duennhaupt, Sarah .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 81 (03) :463-469
[7]  
Brodin I., 2009, THESIS
[8]   Thermal and mechanical properties of electrospun PMMA, PVC, Nylon 6, and Nylon 6,6 [J].
Carrizales, Clarisa ;
Pelfrey, Sean ;
Rincon, Roman ;
Eubanks, Thomas M. ;
Kuang, Anxiu ;
McClure, Michael J. ;
Bowlin, Gary L. ;
Macossay, Javier .
POLYMERS FOR ADVANCED TECHNOLOGIES, 2008, 19 (02) :124-130
[9]  
Chak V., 2013, Int. J. Pharm. Teach. Pract, V4, P811
[10]   Review of the oral toxicity of polyvinyl alcohol (PVA) [J].
DeMerlis, CC ;
Schoneker, DR .
FOOD AND CHEMICAL TOXICOLOGY, 2003, 41 (03) :319-326