Lamivudine allows completion of chemotherapy in lymphoma patients with hepatitis B reactivation

被引:0
作者
Silvestri, F [1 ]
Ermacora, A [1 ]
Sperotto, A [1 ]
Patriarca, F [1 ]
Zaja, F [1 ]
Damiani, D [1 ]
Fanin, R [1 ]
Baccarani, M [1 ]
机构
[1] Univ Hosp, Dept Bone Marrow Transplantat, Div Haematol, I-33100 Udine, Italy
关键词
lamivudine; hepatitis B reactivation; chemotherapy; lymphoma;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Reactivation of hepatitis B virus in patients receiving chemotherapy for non-Hodgkin's lymphoma (NHL) may give rise to hepatitis, hepatic failure and death, and prevent further chemotherapy. We report four patients with NHL in whom hepatitis flare-up was observed after two (three patients) and six (one patient) cycles of chemotherapy. After spontaneous recovery, they were treated with Lamivudine (100 mg/day), which enabled completion of chemotherapy without. further hepatitis B reactivation. In one patient, high-dose chemotherapy and autologous stem cell transplantation was also performed. These data suggest a possible role for Lamivudine in preventing hepatitis B reactivation during chemotherapy administration to chronic carriers of the hepatitis B virus. Moreover, it enabled the completion of both standard, and high-dose chemotherapy in patients with previous hepatitis B reactivation.
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页码:394 / 396
页数:3
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