Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

被引：108

作者：

Kothapalli, Sri-Rajasekhar ^{[1
,2
,3
,4
]}

Sonn, Geoffrey A. ^{[5
]}

Choe, Jung Woo ^{[6
]}

Nikoozadeh, Amin ^{[6
]}

Bhuyan, Anshuman ^{[6
]}

Park, Kwan Kyu ^{[6
]}

Cristman, Paul ^{[6
]}

Fan, Richard ^{[5
]}

Moini, Azadeh ^{[6
]}

Lee, Byung Chul ^{[6
]}

Wu, Jonathan ^{[5
]}

Carver, Thomas E. ^{[7
]}

Trivedi, Dharati ^{[5
]}

Shiiba, Lillian ^{[5
]}

Steinberg, Idan ^{[1
,2
]}

Huland, David M. ^{[1
,2
]}

Rasmussen, Morten F. ^{[6
]}

Liao, Joseph C. ^{[5
]}

Brooks, James D. ^{[5
]}

Khuri-Yakub, Pierre T. ^{[6
]}

Gambhir, Sanjiv S. ^{[1
,2
,8
,9
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiol, Mol Imaging Program Stanford, Palo Alto, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Radiol, Bio X Program, Palo Alto, CA 94305 USA

[3] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA

[4] Penn State Univ, Penn State Canc Inst, Coll Med, Hershey, PA 17033 USA

[5] Stanford Univ, Dept Urol, Sch Med, Palo Alto, CA 94305 USA

[6] Stanford Univ, Dept Elect Engn, Palo Alto, CA 94305 USA

[7] Stanford Univ, Ctr Nanoscale Sci & Engn, Edward L Ginzton Lab, Palo Alto, CA 94305 USA

[8] Stanford Univ, Sch Med, Dept Bioengn, Palo Alto, CA 94305 USA

[9] Stanford Univ, Sch Med, Dept Mat Sci & Engn, Palo Alto, CA 94305 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2019年 / 11卷 / 507期

关键词：

INDOCYANINE GREEN; CANCER; CMUT; TOMOGRAPHY; SYSTEM; LIGHT; PROBE; PZT; PET;

D O I：

10.1126/scitranslmed.aav2169

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.

引用

页数：12

共 58 条

[1] Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer [J].

Afshar-Oromieh, Ali ;

Zechmann, Christian M. ;

Malcher, Anna ;

Eder, Matthias ;

Eisenhut, Michael ;

Linhart, Heinz G. ;

Holland-Letz, Tim ;

Hadaschik, Boris A. ;

Giesel, Frederik L. ;

Debus, Juergen ;

Haberkorn, Uwe .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (01) :11-20

[2]

Akorn Inc, 2006, IC GREEN IND GREEN I

[3] A Review of Indocyanine Green Fluorescent Imaging in Surgery [J].

Alander, Jarmo T. ;

Kaartinen, Ilkka ;

Laakso, Aki ;

Patila, Tommi ;

Spillmann, Thomas ;

Tuchin, Valery V. ;

Venermo, Maarit ;

Valisuo, Petri .

INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING, 2012, 2012

[4]

[Anonymous], IEEE INT ULTR S

[5]

BAKER KJ, 1966, P SOC EXP BIOL MED, V122, P957

[6] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[7] 3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber [J].

Bauer, Daniel R. ;

Olafsson, Ragnar ;

Montilla, Leonardo G. ;

Witte, Russell S. .

JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (02)

[8] Transurethral light delivery for prostate photoacoustic imaging [J].

Bell, Muyinatu A. Lediju ;

Guo, Xiaoyu ;

Song, Danny Y. ;

Boctor, Emad M. .

JOURNAL OF BIOMEDICAL OPTICS, 2015, 20 (03)

[9] In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging [J].

Bell, Muyinatu A. Lediju ;

Kuo, Nathanael P. ;

Song, Danny Y. ;

Kang, Jin U. ;

Boctor, Emad M. .

JOURNAL OF BIOMEDICAL OPTICS, 2014, 19 (12)

[10] Prostate cancer: Evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging - Initial experience [J].

Buckley, DL ;

Roberts, C ;

Parker, GJM ;

Logue, JP ;

Hutchinson, CE .

RADIOLOGY, 2004, 233 (03) :709-715

← 1 2 3 4 5 6 →