Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus

被引：171

作者：

Simola, Daniel F. ^{[1
,2
]}

Graham, Riley J. ^{[2
,3
]}

Brady, Cristina M. ^{[1
,2
]}

Enzmann, Brittany L. ^{[4
]}

Desplan, Claude ^{[5
]}

Ray, Anandasankar ^{[6
]}

Zwiebel, Laurence J. ^{[7
]}

Bonasio, Roberto ^{[1
,2
]}

Reinberg, Danny ^{[8
]}

Liebig, Juergen ^{[4
]}

Berger, Shelley L. ^{[1
,2
,3
,9
]}

机构：

[1] Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Program Epigenet, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[4] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA

[5] NYU, Dept Biol, New York, NY 10003 USA

[6] Univ Calif Riverside, Dept Entomol, Riverside, CA 92521 USA

[7] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37232 USA

[8] NYU, Sch Med, Dept Mol Pharmacol & Biochem, New York, NY 10016 USA

[9] Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2016年 / 351卷 / 6268期

关键词：

DIVISION-OF-LABOR; GENOME-WIDE; HISTONE H3; MEMORY; ACETYLATION; PLASTICITY; IDENTIFICATION; TRANSCRIPTION; INHIBITOR; COMPLEX;

D O I：

10.1126/science.aac6633

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.

引用

页数：9

共 48 条

[11] Mushroom body volumes and visual interneurons in ants: Comparison between sexes and castes
Ehmer, B
Gronenberg, W
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 469 (02) : 198 - 213
[12] Recovery of learning and memory is associated with chromatin remodelling
Andre Fischer
Farahnaz Sananbenesi
Xinyu Wang
Matthew Dobbin
Li-Huei Tsai
[J]. Nature, 2007, 447 (7141) : 178 - 182
[13] Genetic Modulation of Rpd3 Expression Impairs Long-Term Courtship Memory in Drosophila
Fitzsimons, Helen L.
Scott, Maxwell J.
[J]. PLOS ONE, 2011, 6 (12):
[14] The evolution of worker caste diversity in social insects
Fjerdingstad, EJ
Crozier, RH
[J]. AMERICAN NATURALIST, 2006, 167 (03) : 390 - 400
[15] Population and colony structure of the carpenter ant Camponotus floridanus
Gadau, J
Heinze, J
Holldobler, B
Schmid, M
[J]. MOLECULAR ECOLOGY, 1996, 5 (06) : 785 - 792
[16] Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M
Minucci, S
Zhu, P
Krämer, OH
Schimpf, A
Giavara, S
Sleeman, JP
Lo Coco, F
Nervi, C
Pelicci, PG
Heinzel, T
[J]. EMBO JOURNAL, 2001, 20 (24) : 6969 - 6978
[17] Gronenberg W, 1996, J EXP BIOL, V199, P2011
[18] Reversible switching between epigenetic states in honeybee behavioral subcastes
Herb, Brian R.
Wolschin, Florian
Hansen, Kasper D.
Aryee, Martin J.
Langmead, Ben
Irizarry, Rafael
Amdam, Gro V.
Feinberg, Andrew P.
[J]. NATURE NEUROSCIENCE, 2012, 15 (10) : 1371 - 1373
[19] HOLLDOBLER B, 1971, Z VERGL PHYSIOL, V75, P123
[20] Holldobler B., 1990, pi

← 1 2 3 4 5 →