Improved Poly(3,4-Ethylenedioxythiophene) (PEDOT) for Neural Stimulation

被引:35
作者
Mandal, Himadri Shekhar [1 ]
Kastee, Jemika Shrestha [1 ]
McHail, Daniel Glenn [2 ]
Rubinson, Judith Faye [3 ]
Pancrazio, Joseph Jewell [1 ]
Dumas, Theodore Constantine [2 ]
机构
[1] George Mason Univ, Dept Bioengn, 4400 Univ Dr,MS 1G5, Fairfax, VA 22030 USA
[2] George Mason Univ, Krasnow Inst Adv Study, Dept Mol Neurosci, Fairfax, VA 22030 USA
[3] Georgetown Univ, Dept Chem, Washington, DC 20057 USA
来源
NEUROMODULATION | 2015年 / 18卷 / 08期
关键词
Conductive polymer; neural stimulation; PEDOT; SILICON MICROELECTRODE ARRAYS; TISSUE-RESPONSE; MORPHOLOGY; IRIDIUM; FILMS; ENCAPSULATION; ELECTRODES; INTERFACES; STABILITY; CORTEX;
D O I
10.1111/ner.12285
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: This study compares the stability of three variations of the conductive polymer poly(3,4-ethylenedioxythiophene) or PEDOT for neural micro-stimulation under both in vitro and in vivo conditions. We examined PEDOT films deposited with counterions tetrafluoroborate (TFB) and poly(styrenesulfonate) (PSS), and PEDOT:PSS combined with carbon nanotubes (CNTs). Methods: For the in vitro stability evaluation, implantable micro-wires were coated with the polymers, placed in a vial containing phosphate buffered saline (PBS) under accelerated aging conditions (60 degrees C), and current pulses were applied. The resulting voltage profile was monitored over time. Following the same polymer deposition protocol, chronic neural micro-probes were modified and implanted in the motor cortex of two rats for the in vivo stability comparison. Similar stimulating current pulses were applied and the output voltage was examined. The electrochemical impedance spectroscopic (EIS) data were also recorded and fit to an equivalent circuit model that incorporates and quantifies the time-dependent polymer degradation and impedance associated with tissue surrounding each micro-electrode site. Results: Both in vitro and in vivo voltage output profiles show relatively stable behavior for the PEDOT:TFB modified micro-electrodes compared to the PEDOT:PSS and CNT:PEDOT:PSS modified ones. EIS modeling demonstrates that the time-dependent increase in the polymeric resistance is roughly similar to the rise in the respective voltage output in vivo and indicates that the polymeric stability and conductivity, rather than the impedance due to the tissue response, is the primary factor determining the output voltage profile. It was also noted that the number of electrodes showing unit activity post-surgery did not decay for PEDOT:TFB as was the case for PEDOT:PSS and CNT:PEDOT:PSS. Conclusions: PEDOT:TFB may be an enabling material for achieving long lasting micro-stimulation and recording.
引用
收藏
页码:657 / 663
页数:7
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