Unsuccessful allogeneic and autologous transplants after prolonged interferon-α treatment in a pediatric patient with chronic myeloid leukemia

被引：0
作者：
Pérez-Caballero, C
Maldonado, MS
Tamariz, R
de Oteyza, JP
Muñoz, A
机构：
[1] Univ Alcala, Raman & Cajal Hosp, Dept Pediat, E-28034 Madrid, Spain
[2] Univ Alcala, Raman & Cajal Hosp, Dept Hematol, E-28034 Madrid, Spain
来源：
HAEMATOLOGICA | 2000年 / 85卷 / 01期
关键词：
chronic myelogenous leukemia; interferon-alpha; hematopoietic progenitor cells transplant; graft failure;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recombinant or partially pure human leukocyte interferon-alpha (IFN-alpha) has shown promising activity in the treatment of chronic myeloid leukemia (CML)(1,2) However, IFN-alpha might inhibit self-renewal of the progenitor cells in CML3 and may result in irreversible alterations of the marrow microenvironment.(4,5) This pediatric case report seems to confirm the negative impact of prolonged IFN-alpha treatment on subsequent stem cell transplantation.
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收藏
页码：105 / 106
页数：2
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