4-(4-Chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one monohydrate

The asymmetric unit of the title compound, C(16)H(12)ClF(3)N(2)O(3)S center dot H(2)O, contains two crystallographically independent organic molecules and two water molecules. The organic species are linked by an intermolecular O-H center dot center dot center dot O hydrogen bond, while the water molecules are connected to them through intermolecular O-H center dot center dot center dot N hydrogen bonds. The thiophene and phenyl rings are oriented at dihedral angles of 62.35 (4) in the first independent molecule and 60.74 (5)degrees in the second, while the pyrimidine rings adopt twisted conformations in both molecules. Intramolecular N-H center dot center dot center dot F interactions result in the formation of two five-membered rings having envelope conformations. In the crystal structure, further intermolecular O-H center dot center dot center dot O and N-H center dot center dot center dot O hydrogen bonds link the molecules into chains.