Transcriptional Regulation of Sphingosine Kinase 1

被引：17

作者：

Bonica, Joseph ^{[1
]}

Mao, Cungui ^{[2
,3
]}

Obeid, Lina M. ^{[1
,2
,3
]}

Hannun, Yusuf A. ^{[1
,2
,3
]}

机构：

[1] SUNY Stony Brook, Dept Pharmacol, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Canc Ctr, Stony Brook, NY 11794 USA

来源：

CELLS | 2020年 / 9卷 / 11期

关键词：

sphingosine kinase 1; SK1; microRNA; transcription factor; hypoxia; long non-coding RNA; CHRONIC MYELOID-LEUKEMIA; MEDIATES NEUROINFLAMMATION; INHIBITS PROLIFERATION; OSTEOSARCOMA CELLS; LIVER-CANCER; EXPRESSION; SPHK1; HYPOXIA; ANGIOGENESIS; RECEPTOR;

D O I：

10.3390/cells9112437

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways. Sphingosine kinase 1, or SK1, is one of two sphingosine kinases that phosphorylate sphingosine into sphingosine-1-phosphate (S1P). S1P is generally pro-inflammatory, pro-angiogenic, immunomodulatory, and pro-survival; therefore, high SK1 expression and activity have been associated with certain inflammatory diseases and cancer. It is thus important to develop an understanding of the regulation of SK1 expression and activity. In this review, we explore the current literature on SK1 transcriptional regulation, illustrating a complex system of transcription factors, cytokines, and even micro-RNAs (miRNAs) on the post transcriptional level.

引用

页数：12

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