Total body irradiation and pneumonitis risk: a review of outcomes

被引：68
作者：
Carruthers, SA
Wallington, M
机构：
[1] Royal Adelaide Hosp, Dept Radiat Oncol, Ctr Canc, Adelaide, SA 5000, Australia
[2] Univ Tasmania, Dept Radiat Oncol, Royal Hobart Hosp, Hobart, Tas 7000, Australia
来源：
BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 11期
关键词：
total body irradiation; interstitial pneumonitis;
D O I：
10.1038/sj.bjc.6601751
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A review was undertaken of all patients treated at Royal Adelaide Hospital, South Australia with total body irradiation (TBI) for the purpose of assessing the incidence of interstitial pneumonitis (IP) and possible prognostic factors for its development. The aim was also to assess the impact of IP and other prognostic factors on long-term survival outcome following bone marrow transplantation. A total of 84 patients received TBI, with 12 Gy in six fractions delivered using two different instantaneous dose rates of 7.5 and 15 cGy min(-1). This series included 26 cases of acute lymphoblastic leukaemia, 26 of multiple myeloma and 15 of acute myelogenous leukaemia. On multivariate analysis, a higher dose rate was independently significant for an increased risk of IP. (C) 2004 Cancer Research UK Published online 4 May 2004.
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收藏
页码：2080 / 2084
页数：5
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