Role of Notch signaling pathway in pancreatic cancer

被引：3

作者：

Gao, Jiankun ^{[1
]}

Long, Bo ^{[2
]}

Wang, Zhiwei ^{[3
,4
]}

机构：

[1] Sichuan Coll Trandit Chinese Med, Mianyang, Sichuan, Peoples R China

[2] Mianyang 404 Hosp, Dept Infect Dis, Mianyang, Sichuan, Peoples R China

[3] Soochow Univ, Jiangsu Inst Hematol, Affiliated Hosp 1, Cyrus Tang Hematol Ctr, Suzhou 215123, Peoples R China

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave,CLS 628B, Boston, MA 02215 USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2017年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer; notch; cellular signaling; therapy; target; NF-KAPPA-B; INHIBITS CELL-GROWTH; EPITHELIAL-MESENCHYMAL TRANSITION; SMALL-MOLECULE INHIBITOR; RECEPTOR-RELATED PROTEIN; ASPARAGINYL BETA-HYDROXYLASE; STEM-CELLS; TUMOR-SUPPRESSOR; SONIC-HEDGEHOG; IN-VITRO;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It has been shown that multiple signaling pathways are involved in the pathogenesis of PC, such as JNK, PI3K/AKT, Rho GTPase, Hedgehog (Hh) and Skp2. In recent years, accumulated evidence has demonstrated that Notch signaling pathway plays critical roles in the development and progression of PC. Therefore, in this review we discuss the recent literature regarding the function and regulation of Notch in the pathogenesis of PC. Moreover, we describe that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, which could be a novel approach for the treatment of PC patients.

引用

页码：173 / 186

页数：14

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