Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

被引：4
作者：
Andersen, Emil [1 ]
Altintas, Ali [1 ]
Andersson-Hall, Ulrika [2 ]
Holmang, Agneta [2 ]
Barres, Romain [1 ]
机构：
[1] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
[2] Univ Gothenburg, Dept Physiol, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden
来源：
EPIGENOMICS | 2019年 / 11卷 / 08期
基金：
瑞典研究理事会;
关键词：
DNA methylation; epigenetic inheritance; gestational diabetes; obesity; pregnancy; WIDE DNA METHYLATION; CORD BLOOD; INTRAUTERINE EXPOSURE; PROMOTER; PREGNANCY; PROFILES; MELLITUS;
D O I：
10.2217/epi-2019-0055
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors. Methods: We profiled the DNA methylation sihgnature of blood from lean, obese and GDM mothers and their respective newborns. Results: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group. Conclusion: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.
引用
收藏
页码：861 / 874
页数：14
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