A novel method for sequence independent incorporation of activated/protected cysteine in Fmoc solid phase peptide synthesis

被引：16

作者：

Ghosh, AK

Fan, E

机构：

[1] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA

[2] Univ Washington, Biomol Struct Ctr, Seattle, WA 98195 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(99)02045-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In conventional stepwise Fmoc solid phase peptide synthesis, incorporation of cysteine with nitro-pyridine sulfenyl (Npys) or pyridine sulfenyl (Pys) groups which act as an activation/protection of the thiol function has been accomplished in a sequence independent manner. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：165 / 168

页数：4

共 8 条

[1] PROTEIN THIOLATION AND REVERSIBLE PROTEIN-PROTEIN CONJUGATION - N-SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE, A NEW HETEROBIFUNCTIONAL REAGENT [J].