Role of lymphatic vasculature in regional and distant metastases

被引：63

作者：

Podgrabinska, Simona ^{[1
]}

Skobe, Mihaela ^{[2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA

[3] Tisch Canc Inst Mt Sinai, New York, NY 10029 USA

来源：

MICROVASCULAR RESEARCH | 2014年 / 95卷

关键词：

Lymphangiogenesis; Metastasis; Lymphatic endothelium; Immunoregulation; Chemokine; VEGF-C; VEGFR-3; CCL1; CCR8; Lymph node; ENDOTHELIAL-GROWTH-FACTOR; PULMONARY LYMPHANGITIC CARCINOMATOSIS; C-INDUCED LYMPHANGIOGENESIS; DENDRITIC-CELL TRAFFICKING; LYMPHOID-TISSUE CHEMOKINE; BREAST-CANCER METASTASIS; NODE METASTASIS; VEGF-C; T-CELLS; TUMOR LYMPHANGIOGENESIS;

D O I：

10.1016/j.mvr.2014.07.004

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In cancer, lymphatic vasculature has been traditionally viewed only as a transportation system for metastatic cells. It has now become clear that lymphatics perform many additional functions which could influence cancer progression. Lymphangiogenesis, induced at the primary tumor site and at distant sites, potently augments metastasis. Lymphatic endothelial cells (LECs) control tumor cell entry and exit from the lymphatic vessels. LECs also control immune cell traffic and directly modulate adaptive immune responses. This review highlights advances in our understanding of the mechanisms by which lymphatic vessels, and in particular lymphatic endothelium, impact metastasis. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：46 / 52

页数：7

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