Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile

被引：24
|
作者：
Zhang, Wandi
Haskins, Christopher W.
Yang, Yang
Dai, Mingji [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 45期
关键词：
CONVERTING PRIMARY AMIDES; MILD CONDITIONS; ACID AMIDES; DEHYDRATION; CONVENIENT; CONVERSION; CARBOXAMIDES; LYCONADINS; ALDOXIMES; CYANATION;
D O I：
10.1039/c4ob01825g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including alpha,beta,gamma,delta-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.
引用
收藏
页码：9109 / 9112
页数：4
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