IFITM proteins - cellular inhibitors of viral entry

被引：101
作者：
Smith, S. E. [1 ]
Weston, S. [2 ]
Kellam, P. [1 ,3 ]
Marsh, M. [2 ]
机构：
[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
[2] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England
[3] UCL, Div Infect & Immun, MRC UCL Ctr Med Mol Virol, London WC1E 6BT, England
来源：
CURRENT OPINION IN VIROLOGY | 2014年 / 4卷
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;
关键词：
INDUCED TRANSMEMBRANE PROTEIN-3; ANTIVIRAL ACTIVITY; S-PALMITOYLATION; HIV-1; INFECTION; VIRUS; RESTRICTS; GENE; RESISTANCE; TETHERIN; FAMILY;
D O I：
10.1016/j.coviro.2013.11.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.
引用
收藏
页码：71 / 77
页数：7
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