An efficacy trial of the malaria vaccine SPf66 in Gambian infants - second year of follow-up

被引：12

作者：

Bojang, KA

Obaro, SK

DAlessandro, U

Bennett, S

Langerock, P

Targett, GAT

Greenwood, BM

机构：

[1] LONDON SCH HYG & TROP MED,LONDON WC1,ENGLAND

[2] MRC LABS,FAJARA,GAMBIA

[3] INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM

来源：

VACCINE | 1998年 / 16卷 / 01期

基金：

英国医学研究理事会;

关键词：

malaria; Plasmodium falciparum; malaria vaccine; SPf66;

D O I：

10.1016/S0264-410X(97)00159-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1994, 630 Gambian infants were immunized with three doses of the synthetic polypeptide malaria vaccine SPf66 or with a control vaccine. No significant protection against first or total attacks of malaria was observed among the children who received SPf66. However the period of follow-up was short. Thus, 532 children were followed for a second malaria transmission season during which 291 episodes of malaria were detected. Protective efficacies of SPf66 against first attacks of malaria and against all attacks of malaria were 8% [95% CI -20%, 30%] and 2% [95% CI -26% 24%] respectively. SPf66 did not provide any significant degree of protection to Gambian infants during a second year of follow-up. (C) 1997 Elsevier Science Ltd.

引用

页码：62 / 67

页数：6

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