Fibroblast growth factor 20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese

被引：13
作者：
Xu, Xiaofeng [1 ,2 ]
Wang, Naidong [3 ]
Xu, Huamin [1 ,2 ]
Xie, Anmu [3 ]
Jiang, Hong [1 ,2 ]
Xie, Junxia [1 ,2 ]
机构：
[1] Qingdao Univ, Dept Physiol, Shandong Prov Key Lab Pathogenesis & Prevent Neur, Coll Med, Qingdao 266071, Peoples R China
[2] Qingdao Univ, State Key Disciplines Physiol, Coll Med, Qingdao 266071, Peoples R China
[3] Qingdao Univ, Dept Neurol, Affiliated Hosp, Coll Med, Qingdao 266071, Peoples R China
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2013年 / 20卷 / 11期
关键词：
FGF20; Parkinson's disease; Polymorphism; LRRK2 EXONIC VARIANTS; ALPHA-SYNUCLEIN; DOPAMINERGIC-NEURONS; STEM-CELLS; ASSOCIATION; FGF20; RISK; DIFFERENTIATION; OVEREXPRESSION; MODULATION;
D O I：
10.1016/j.jocn.2013.02.023
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fibroblast growth factor (FGF) 20 is a neurotrophic factor that exerts strong neurotrophic properties in the brain and could significantly enhance the survival of rat midbrain dopaminergic neurons. The genetic association of the FGF20 gene with Parkinson's disease (PD) remains controversial. We used the polymerase chain reaction-restriction length polymorphism assay to assess the association of two single nucleotide polymorphisms, rs12720208 and rs1721100, within the FGF20 gene in 178 PD patients and 190 healthy controls from a Northern Han Chinese population. The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between PD patients and controls. This indicates the FGF20 gene might not play a major role in the genetic predisposition to PD in this population. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1588 / 1590
页数：3
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