N-cadherin signaling in synapse formation and neuronal physiology

被引:58
作者
Bruses, Juan L. [1 ]
机构
[1] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66103 USA
关键词
N-cadherin; synapse formation; Rho GTPases; calcium current; catenins; juxtamembrane domain; actin cytoskeleton;
D O I
10.1385/MN:33:3:237
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neural cadherin (N-cadherin) is an adhesion receptor that is localized in abundance at neuron-to-neuron synapses. N-cadherin contains an extracellular domain that binds to other cadherins on juxtaposed cell membranes, a single-pass transmembrane region, and a cytoplasmic tail that interacts with various proteins, including catenins, kinases, phosphatases, and presenilin 1. N-cadherin contributes to the structural and functional organization of the synaptic complex by ensuring the adhesion between synaptic membranes and organizing the underlying actin cytoskeleton. Additionally, recent findings have shown that N-cadherin may participate in synaptic physiology by regulating calcium influx through voltage-activated calcium currents. The diverse activities of N-cadherin stem from its ability to operate as both an adhesion molecule that links cytoskeletons across cell membranes and a ligand-activated homophilic receptor capable of initiating intracellular signaling. An important mechanism of cadherin signaling is the regulation of small Rho guanosine triphosphatase activity that affects cytoskeleton. dynamics and calcium influx. Because both the regulation of cadherin adhesive activity and cadherin-mediated signaling are affected by the binding of molecules to the intracellular domain, changes in the composition of the N-cadherin complex are central to the regulation of cadherin-mediated functions. This article focuses on the roles that N-cadherin might play at the level of the synapse through its effect on adhesion and signaling in the proximity of the synaptic junction.
引用
收藏
页码:237 / 252
页数:16
相关论文
共 156 条
[1]   Vav2 is an activator of Cdc42, Rac1, and RhoA [J].
Abe, K ;
Rossman, KL ;
Liu, B ;
Ritola, KD ;
Chiang, D ;
Campbell, SL ;
Burridge, K ;
Der, CJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10141-10149
[2]   Stability of dendritic spines and synaptic contacts is controlled by αN-catenin [J].
Abe, K ;
Chisaka, O ;
van Roy, F ;
Takeichi, M .
NATURE NEUROSCIENCE, 2004, 7 (04) :357-363
[3]  
ABERLE H, 1994, J CELL SCI, V107, P3655
[4]   Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase) [J].
Amano, M ;
Ito, M ;
Kimura, K ;
Fukata, Y ;
Chihara, K ;
Nakano, T ;
Matsuura, Y ;
Kaibuchi, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20246-20249
[5]  
Anastasiadis PZ, 2000, J CELL SCI, V113, P1319
[6]   Regulation of Rho GTPases by p120-catenin [J].
Anastasiadis, PZ ;
Reynolds, AB .
CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) :604-610
[7]   Inhibition of RhoA by p120 catenin [J].
Anastasiadis, PZ ;
Moon, SY ;
Thoreson, MA ;
Mariner, DJ ;
Crawford, HC ;
Zheng, Y ;
Reynolds, AB .
NATURE CELL BIOLOGY, 2000, 2 (09) :637-644
[8]   p120ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells [J].
Aono, S ;
Nakagawa, S ;
Reynolds, AB ;
Takeichi, M .
JOURNAL OF CELL BIOLOGY, 1999, 145 (03) :551-562
[9]   Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex [J].
Baki, L ;
Marambaud, P ;
Efthimiopoulos, S ;
Georgakopoulos, A ;
Wen, P ;
Cui, W ;
Shioi, J ;
Koo, E ;
Ozawa, M ;
Friedrich, VL ;
Robakis, NK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2381-2386
[10]   Role of β-catenin in synaptic vesicle localization and presynaptic assembly [J].
Bamji, SX ;
Shimazu, K ;
Kimes, N ;
Huelsken, J ;
Birchmeier, W ;
Lu, B ;
Reichardt, LF .
NEURON, 2003, 40 (04) :719-731