Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin-Induced Gastric Ulcer

被引:10
作者
Atalay, Fadime [1 ]
Odabasoglu, Fehmi [1 ]
Halici, Mesut
Cakir, Ahmet [2 ,3 ]
Cadirci, Elif [4 ]
Aslan, Ali [5 ]
Berktas, Ozlem Aydin [6 ]
Kazaz, Cavit [7 ]
机构
[1] Kafkas Univ, Fac Med, Dept Biochem, TR-36200 Kars, Turkey
[2] Ataturk Univ, Fac Vet, Dept Chem, TR-25240 Erzurum, Turkey
[3] Kilis 7 Aralik Univ, Fac Sci, Dept Chem, TR-79000 Kilis, Turkey
[4] Ataturk Univ, Fac Pharm, Dept Pharmacol, TR-25240 Erzurum, Turkey
[5] Ataturk Univ, Kazim Karabekir Educ Fac, Dept Biol, TR-25240 Erzurum, Turkey
[6] Ataturk Univ, Fac Pharm, Dept Biochem, TR-25240 Erzurum, Turkey
[7] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey
关键词
LIPID-PEROXIDATION; NITRIC-OXIDE; NEUTROPHIL-INFILTRATION; RESTRAINT STRESS; USNEA-LONGISSIMA; MUCOSAL LESIONS; RATS; RADICALS; ACID; PATHOGENESIS;
D O I
10.1002/cbdv.201400432
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two lichen metabolites, rhizonaldehyde (1) and rhizonyl alcohol (2), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D- and 2D-NMR spectroscopic methods. The gastroprotective and in vivo antioxidant activities of extracts of L. pulmonaria and its metabolites, 1 and 2, were investigated in indomethacin-induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl3 extracts, with 75.3-41.5% inhibition. Rhizonyl alcohol (2) significantly reduced the gastric lesions with an inhibition rate of 84.6-42.8%, whereas rhizonaldehyde (1) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (2) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (2) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (2) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues.
引用
收藏
页码:1756 / 1767
页数:12
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