Fertility in the aging male: a systematic review

被引：28
作者：
Jimbo, Masaya [1 ]
Kunisaki, Jason [2 ]
Ghaed, Mohammadali [3 ]
Yu, Victor [4 ]
Flores, Hunter A. [5 ]
Hotaling, James M. [1 ]
机构：
[1] Univ Utah, Div Urol, Dept Surg, Sch Med, Salt Lake City, UT USA
[2] Univ Utah, Dept Human Genet, Salt Lake City, UT USA
[3] Iran Univ Med Sci, Rasool Akram Hosp, Urol Dept, Tehran, Iran
[4] Univ Nevada, Reno Sch Med, Reno, NV USA
[5] Baylor Coll Med, Scott Dept Urol, Houston, TX USA
来源：
FERTILITY AND STERILITY | 2022年 / 118卷 / 06期
关键词：
Male infertility; andrology; paternal age; ASSISTED REPRODUCTIVE TECHNOLOGY; SPERM DNA FRAGMENTATION; IN-VITRO FERTILIZATION; ADVANCED PATERNAL AGE; MALE BIOLOGICAL CLOCK; DE-NOVO MUTATIONS; SEMEN PARAMETERS; INTRACYTOPLASMIC SPERM; OXIDATIVE STRESS; MALE-INFERTILITY;
D O I：
10.1016/j.fertnstert.2022.10.035
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The negative effect of advanced female age on fertility and offspring health is well understood. In comparison, much less is known about the implications of male age on fertility, with many studies showing conflicting results. Nevertheless, increasing evidence suggests that advanced paternal age has negative effects on sperm parameters, reproductive success, and offspring health. Herein, we summarize the current body of knowledge on this controversial topic, with the belief that this review will serve as a resource for the clinicians providing fertility counseling to couples with older male partners. (C) 2022 by American Society for Reproductive Medicine.
引用
收藏
页码：1022 / 1034
页数：13
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