High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication

被引：9

作者：

Mauroy, Axel ^{[1
]}

Taminiau, Bernard ^{[2
]}

Nezer, Carine ^{[3
]}

Ghurburrun, Elsa ^{[1
]}

Baurain, Denis ^{[4
]}

Daube, Georges ^{[2
]}

Thiry, Etienne ^{[1
]}

机构：

[1] Univ Liege, Vet Virol & Anim Viral Dis, Fundamental & Appl Res Anim & Hlth Ctr, Fac Vet Med, Liege, Belgium

[2] Univ Liege, Food Microbiol, Fundamental & Appl Res Anim & Hlth Ctr, Fac Vet Med, Liege, Belgium

[3] Qual Partner SA, Herstal, Belgium

[4] Univ Liege, Dept Life Sci, Eukaryot Phylogen, Liege, Belgium

来源：

ARCHIVES OF VIROLOGY | 2017年 / 162卷 / 04期

关键词：

Norovirus; Murine; Next-generation sequencing; Genetic diversity; Mutation; NORWALK-LIKE VIRUSES; POPULATION-DYNAMICS; RNA VIRUS; EVOLUTION; INFECTION; INFERENCE; ACCURATE; PATTERNS; HOSTS;

D O I：

10.1007/s00705-016-3179-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in genomic regions encompassing partial coding sequences for non-structural (NS) 1-2, NS5, NS6, NS7 proteins within open reading frame (ORF) 1. In a region encoding a portion of the major capsid protein (VP1) within ORF2 (also including the ORF4 region) and a portion of the minor structural protein (VP2), the mutation rates were estimated to be at least one order of magnitude higher. The VP2 coding region was found to have the highest mutation rate.

引用

页码：1019 / 1023

页数：5

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