Immunotherapy for the treatment of colorectal cancer

被引：20

作者：

Lumish, Melissa A. ^{[1
]}

Cercek, Andrea ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2021年 / 123卷 / 03期

关键词：

checkmate; checkpoint blockade; keynote; microsatellite instability; mismatch repair deficiency; PHASE-II; EFFICACY; PEMBROLIZUMAB; NIVOLUMAB; INHIBITION; IPILIMUMAB; ANTIBODY; THERAPY; RADIOTHERAPY; INFLAMMATION;

D O I：

10.1002/jso.26357

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibition (ICI) has transformed the management of metastatic colorectal cancer (mCRC) with mismatch-repair deficiency (dMMR) and microsatellite instability (MSI-H), though this constitutes on average less than 5% of mCRC, and ICI is ineffective in preserved MMR/microsatellite stable disease (pMMR/MSS). Here we review the efficacy of ICI in dMMR/MSI-H mCRC, poor response to ICI in pMMR/MSS mCRC, role for ICI in locally advanced disease, biomarkers of response, novel immunotherapies, and future directions in targeting resistance mechanisms.

引用

页码：760 / 774

页数：15

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