Biodistribution and clearance of instilled carbon nanotubes in rat lung

被引：91

作者：

Elgrabli, Dan ^{[1
]}

Floriani, Magali ^{[2
]}

Abella-Gallart, Steve ^{[1
]}

Meunier, Laurent ^{[1
]}

Gamez, Christelle ^{[1
]}

Delalain, Patrice ^{[1
]}

Rogerieux, Francoise ^{[1
]}

Boczkowski, Jorge ^{[3
,4
]}

Lacroix, Ghislaine ^{[1
]}

机构：

[1] INERIS, Verneuil En Halatte, France

[2] Inst Radioprotect & Surete Nucl Cadarache IRSN, St Paul Les Durance, France

[3] Univ Paris 07, Fac Med Denis Diderot Site Bichat, INSERM, U700, Paris, France

[4] Hop Bichat Claude Bernard, AP HP, Ctr Invest Clin 007, Paris, France

来源：

PARTICLE AND FIBRE TOXICOLOGY | 2008年 / 5卷 / 1期

关键词：

D O I：

10.1186/1743-8977-5-20

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Background: Constituted only by carbon atoms, CNT are hydrophobic and hardly detectable in biological tissues. These properties make biokinetics and toxicology studies more complex. Methods: We propose here a method to investigate the biopersistence of CNT in organism, based on detection of nickel, a metal present in the MWCNT we investigated. Results and conclusion: Our results in rats that received MWCNT by intratracheal instillation, reveal that MWCNT can be eliminated and do not significantly cross the pulmonary barrier but are still present in lungs 6 months after a unique instillation. MWCNT structure was also showed to be chemically modified and cleaved in the lung. These results provide the first data of CNT biopersistence and clearance at 6 months after respiratory administration.

引用

收藏

页数：13

相关论文

共 22 条

[1] Getting rid of the bodies: A specialized form of phagocytosis [J].

Alibert, M ;

Chimini, G .

M S-MEDECINE SCIENCES, 2002, 18 (8-9) :853-860

[2] Multi-walled carbon nanotubes induce T lymphocyte apoptosis [J].

Bottini, M ;

Bruckner, S ;

Nika, K ;

Bottini, N ;

Bellucci, S ;

Magrini, A ;

Bergamaschi, A ;

Mustelin, T .

TOXICOLOGY LETTERS, 2006, 160 (02) :121-126

[3]

Cassell AM, 1999, J PHYS CHEM B, V103, P6484, DOI 10.1021/jp990957sCCC:$18.00

[4] Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells [J].

Cherukuri, P ;

Bachilo, SM ;

Litovsky, SH ;

Weisman, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (48) :15638-15639

[5] Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence [J].

Cherukuri, Paul ;

Gannon, Christopher J. ;

Leeuw, Tonya K. ;

Schmidt, Howard K. ;

Smalley, Richard E. ;

Curley, Steven A. ;

Weisman, R. Bruce .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (50) :18882-18886

[6] Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes [J].

Elgrabli, D. ;

Abella-Gallart, S. ;

Robidel, F. ;

Rogerieux, F. ;

Boczkowski, J. ;

Lacroix, G. .

TOXICOLOGY, 2008, 253 (1-3) :131-136

[7] Effect of BSA on carbon nanotube dispersion for in vivo and in vitro studies [J].

Elgrabli, Dan ;

Abella-Gallart, Steve ;

Aguerre-Chariol, Olivier ;

Robidel, Franck ;

Rogerieux, Francoise ;

Boczkowski, Jorge ;

Lacroix, Ghislaine .

NANOTOXICOLOGY, 2007, 1 (04) :266-278

[8] Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF [J].

Fadok, VA ;

Bratton, DL ;

Konowal, A ;

Freed, PW ;

Westcott, JY ;

Henson, PM .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) :890-898

[9] In vitro study of the pulmonary translocation of nanoparticles - A preliminary study [J].

Geys, J ;

Coenegrachts, L ;

Vercammen, J ;

Engelborghs, Y ;

Nemmar, A ;

Nemery, B ;

Hoet, PHM .

TOXICOLOGY LETTERS, 2006, 160 (03) :218-226

[10] CATALYTIC GROWTH OF SINGLE-WALLED NANOTUBES BY LASER VAPORIZATION [J].

GUO, T ;

NIKOLAEV, P ;

THESS, A ;

COLBERT, DT ;

SMALLEY, RE .

CHEMICAL PHYSICS LETTERS, 1995, 243 (1-2) :49-54