Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir

被引：75
作者：
Hoetelmans, RMW
Meenhorst, PL
Mulder, JW
Burger, DM
Koks, CHW
Beijnen, JH
机构：
[1] SLOTERVAART HOSP, DEPT INTERNAL MED, NL-1066 EC AMSTERDAM, NETHERLANDS
[2] UNIV NIJMEGEN HOSP, DEPT CLIN PHARM, NL-6500 HB NIJMEGEN, NETHERLANDS
来源：
PHARMACY WORLD & SCIENCE | 1997年 / 19卷 / 04期
关键词：
clinical pharmacology; HIV infection; protease inhibitor; ritonavir; saquinavir;
D O I：
10.1023/A:1008629608556
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this review the clinical pharmacology of HIV protease inhibitors, a new class of antiretroviral drugs, is discussed. After considering HIV protease function and structure, the development of inhibitors of HIV protease is presented. Three protease inhibitors are reviewed in more detail: saquinavir, indinavir, and ritonavir. Clinical trial results with these agents are evaluated. Furthermore, adverse effects, resistance, dosage and administration, clinical pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, and drug interactions are discussed.
引用
收藏
页码：159 / 175
页数：17
相关论文
共 91 条
[21]  
DANNER SA, 1996, ABB SAT S 3 INT C DR
[22]  
Darke P L, 1994, Adv Pharmacol, V25, P399, DOI 10.1016/S1054-3589(08)60438-X
[23]  
DEWIT S, 1996, 36 INT C ANT AG CHEM, pA26
[24]   IN-VITRO SELECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESISTANT TO RO 31-8959 PROTEINASE-INHIBITOR [J].
DIANZANI, F ;
ANTONELLI, G ;
TURRIZIANI, O ;
RIVA, E ;
DONG, G ;
BELLAROSA, D .
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1993, 4 (06) :329-333
[25]   L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR [J].
DORSEY, BD ;
LEVIN, RB ;
MCDANIEL, SL ;
VACCA, JP ;
GUARE, JP ;
DARKE, PL ;
ZUGAY, JA ;
EMINI, EA ;
SCHLEIF, WA ;
QUINTERO, JC ;
LIN, JH ;
CHEN, IW ;
HOLLOWAY, MK ;
FITZGERALD, PMD ;
AXEL, MG ;
OSTOVIC, D ;
ANDERSON, PS ;
HUFF, JR .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (21) :3443-3451
[26]   RESISTANCE OF HIV TYPE-1 TO PROTEINASE-INHIBITOR RO-31-8959 [J].
EBERLE, J ;
BECHOWSKY, B ;
ROSE, D ;
HAUSER, U ;
VONDERHELM, K ;
GURTLER, L ;
NITSCHKO, H .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (06) :671-676
[27]  
FALLOON J, 1995, 35 INT C ANT AG CHEM, P186
[28]  
FALLOON J, 1996, 36 INT C ANT AG CHEM, P1108
[29]  
FARRAR G, 1994, BR J CLIN PHARM, V38, pP162
[30]   THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
FISCHL, MA ;
RICHMAN, DD ;
GRIECO, MH ;
GOTTLIEB, MS ;
VOLBERDING, PA ;
LASKIN, OL ;
LEEDOM, JM ;
GROOPMAN, JE ;
MILDVAN, D ;
SCHOOLEY, RT ;
JACKSON, GG ;
DURACK, DT ;
KING, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191
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