The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli

被引：85
作者：
Chollet, R
Chevalier, J
Bryskier, A
Pagés, JM
机构：
[1] Univ Med Mediterranee, Fac Med, EA2197, F-13385 Marseille 05, France
[2] Aventis Pharma SA, Infect Dis Grp, Romainville, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期
关键词：
D O I：
10.1128/AAC.48.9.3621-3624.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.
引用
收藏
页码：3621 / 3624
页数：4
相关论文
共 24 条
  • [21] Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae
    Veal, WL
    Yellen, A
    Balthazar, JT
    Pan, WB
    Spratt, BG
    Shafer, WM
    [J]. MICROBIOLOGY-SGM, 1998, 144 : 621 - 627
  • [22] Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
    Yu, EW
    McDermott, G
    Zgurskaya, HI
    Nikaido, H
    Koshland, DE
    [J]. SCIENCE, 2003, 300 (5621) : 976 - 980
  • [23] The ketolides - A critical review
    Zhanel, GG
    Walters, M
    Noreddin, A
    Vercaigne, LM
    Wierzbowski, A
    Embil, JM
    Gin, AS
    Douthwaite, S
    Hoban, DJ
    [J]. DRUGS, 2002, 62 (12) : 1771 - 1804
  • [24] ZONG P, 2000, INFECT DIS RES, V3, P325
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