The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli

被引：85
作者：
Chollet, R
Chevalier, J
Bryskier, A
Pagés, JM
机构：
[1] Univ Med Mediterranee, Fac Med, EA2197, F-13385 Marseille 05, France
[2] Aventis Pharma SA, Infect Dis Grp, Romainville, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期
关键词：
D O I：
10.1128/AAC.48.9.3621-3624.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.
引用
收藏
页码：3621 / 3624
页数：4
相关论文
共 24 条
  • [11] Lorenz J, 2003, INT J CLIN PRACT, V57, P519
  • [12] Porin alteration and active efflux:: two in vivo drug resistance strategies used by Enterobacter aerogenes
    Mallea, M
    Chevalier, J
    Bornet, C
    Eyraud, A
    Davin-Regli, A
    Bollet, C
    Pagès, JM
    [J]. MICROBIOLOGY-UK, 1998, 144 : 3003 - 3009
  • [13] Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates
    Malléa, M
    Mahamoud, A
    Chevalier, J
    Alibert-Franco, S
    Brouant, P
    Barbe, J
    Pagès, JM
    [J]. BIOCHEMICAL JOURNAL, 2003, 376 : 801 - 805
  • [14] Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae
    Ng, LK
    Martin, I
    Liu, G
    Bryden, L
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (09) : 3020 - 3025
  • [15] Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates
    Peric, M
    Bozdogan, B
    Jacobs, MR
    Appelbaum, PC
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (03) : 1017 - 1022
  • [16] The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes
    Pradel, E
    Pagès, JM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (08) : 2640 - 2643
  • [17] Retsema J, 2001, INT J ANTIMICROB AG, V18, pS3, DOI 10.1016/S0924-8579(01)00401-0
  • [18] Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants
    Roberts, MC
    Sutcliffe, J
    Courvalin, P
    Jensen, LB
    Rood, J
    Seppala, H
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (12) : 2823 - 2830
  • [19] The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump
    Sanchez, L
    Pan, W
    Vinas, M
    Nikaido, H
    [J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (21) : 6855 - 6857
  • [20] Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages
    Seral, C
    Michot, JM
    Chanteux, H
    Mingeot-Leclercq, MP
    Tulkens, PM
    Van Bambeke, F
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (03) : 1047 - 1051
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