Ulla: a program for calculating environment-specific amino acid substitution tables

被引：10

作者：

Lee, Semin ^{[1
]}

Blundell, Tom L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

BIOINFORMATICS | 2009年 / 25卷 / 15期

基金：

英国惠康基金;

关键词：

FUNCTIONAL RESTRAINTS; PROTEIN-STRUCTURE; PREDICTION;

D O I：

10.1093/bioinformatics/btp300

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Amino acid residues are under various kinds of local environmental restraints, which influence substitution patterns. Ulla,(1) a program for calculating environment-specific substitution tables, reads protein sequence alignments and local environment annotations. The program produces a substitution table for every possible combination of environment features. Sparse data is handled using an entropy-based smoothing procedure to estimate robust substitution probabilities.

引用

页码：1976 / 1977

页数：2

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