Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease

被引：373

作者：

Sasaki, Makoto

Shibata, Eri

Tohyama, Koujiro

Takahashi, Junko

Otsuka, Kotaro

Tsuchiya, Kuniaki

Takahashi, Satoshi

Ehara, Shigeru

Terayama, Yasuo

Sakai, Akio

机构：

[1] Iwate Med Univ, Dept Radiol, Morioka, Iwate 0208505, Japan

[2] Iwate Med Univ, Ctr EM & Bioimaging Res Neuroanat, Dept Neurol, Morioka, Iwate 0208505, Japan

[3] Iwate Med Univ, Dept Psychiat, Morioka, Iwate 0208505, Japan

[4] Metropolitan Matsuzawa Hosp, Dept Lab Med & Pathol, Tokyo, Japan

来源：

NEUROREPORT | 2006年 / 17卷 / 11期

关键词：

locus ceruleus; magnetic resonance imaging; neuromelanin; Parkinson's disease; substantia nigra;

D O I：

10.1097/01.wnr.0000227984.84927.a7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We carried out an investigation to identify neuromelanin-containing noradrenergic and dopaminergic neurons in the locus ceruleus and substantia nigra pars compacta of healthy volunteers and patients with Parkinson's disease using a newly developed magnetic resonance imaging technique that can demonstrate neuromelanin-related contrast. The high-resolution neuromelanin images obtained by a 3-T scanner revealed high signal areas in the brain stem and these corresponded well with the location of the locus ceruleus and substantia nigra pars compacta in gross specimens. In Parkinson's disease patients, the signal intensity in the locus ceruleus and substantia nigra pars compacta was greatly reduced, suggesting depletion of neuromelanin-containing neurons. We conclude that neuromelanin magnetic resonance imaging can be used for direct visualization of the locus ceruleus and substantia nigra pars compacta, and may help in detecting pathological changes in Parkinson's disease and related disorders.

引用

页码：1215 / 1218

页数：4

共 19 条

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