Antiproliferative Activity of Some Higher Mushrooms from Hungary against Human Cancer Cell Lines

被引：6

作者：

Vanyolos, Attila ^{[1
]}

Kovacs, Bernadett ^{[1
]}

Bozsity, Noemi ^{[2
]}

Zupko, Istvan ^{[2
]}

Hohmann, Judit ^{[1
]}

机构：

[1] Univ Szeged, Dept Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Pharmacodynam & Biopharm, Szeged, Hungary

来源：

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 2015年 / 17卷 / 12期

关键词：

medicinal mushrooms; antiproliferative activity; screening; COLLYBIA-DRYOPHILA; DERIVATIVES; ACIDS;

D O I：

10.1615/IntJMedMushrooms.v17.i12.40

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present work, aqueous and organic extracts of 16 Basidiomycetes mushrooms and 1 Ascomycetes mushroom were investigated in vitro for their antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 68 n-hexane, chloroform, 50% methanol, and water extracts of selected species were screened for their potential cell growth inhibitory activity. Our experiments revealed that 7 of 17 species demonstrated notable antiproliferative activity (at least 50% inhibition of cell proliferation) against one or more cell lines. Kuehneromyces mutabilis, Lactarius quietus, and Lentinellus cochleatus, which exerted the highest activity on cancer cells, are considered valuable species in the perspective of further mycochemical studies.

引用

页码：1145 / 1149

页数：5

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