Clear Cell Variant of Solid Pseudopapillary Neoplasm of the Pancreas: A Report of a Rare Variant and Review of the Literature

被引:0
作者
Costales, Cristina [1 ]
Mehta, Arjun [1 ]
Kulkarni, Sujit [1 ]
Larson, Brent K. [1 ,2 ]
机构
[1] Univ Southern Calif, Los Angeles, CA USA
[2] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA
关键词
solid pseudopapillary neoplasm; pancreas; clear cell; pancreas cancer; pseudopapillary; TUMORS;
D O I
10.1177/1066896919833790
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The clear cell variant of solid pseudopapillary neoplasm (ccSPN) of the pancreas was first described in 2006. In this article, we report a case of this rare variant and review the few published reports. Both the current and previous reports show that ccSPN has several morphologic differences from conventional SPN, including clear vacuoles, fewer pseudopapillary formations, more solid/diffuse architecture, less hemorrhage, and fewer cholesterol clefts. Some of these features peculiar to ccSPN, such as solid/diffuse architecture, have been proposed to suggest aggressive behavior, though reports of ccSPN are rare and often have limited clinical follow-up. ccSPN also appears to occur more frequently in males than conventional SPNs. These clinical and pathologic features lead to unique set of differential diagnostic considerations for ccSPN, including metastatic renal cell carcinoma, perivascular epithelial cell tumor, and clear cell variants of other carcinomas. These unique features, atypical differential, and uncertain prognostic ramifications all make ccSPN an important variant to be aware of and report.
引用
收藏
页码:535 / 540
页数:6
相关论文
共 13 条
  • [1] The clear cell variant of solid pseudopapillary tumor of the pancreas: A previously unrecognized pancreatic neoplasm
    Albores-Saavedra, Jorge
    Simpson, Karen W.
    Bilello, Seth J.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (10) : 1237 - 1242
  • [2] Clear cell variant of solid pseudopapillary neoplasm of pancreas diagnosed by fine needle aspiration: A case report and review of the literature
    Canberk, Sule
    Elcin, Bilge Baskir
    Uludokumaci, Atay
    Uygun, Nesrin
    Gulsen, Fatih
    [J]. CYTOJOURNAL, 2013, 10
  • [3] Metastatic Renal Cell Carcinoma to the Pancreas A Review
    Cheng, Shaun Kian Hong
    Chuah, Khoon Leong
    [J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2016, 140 (06) : 598 - 602
  • [4] Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathologic and Survival Analyses of 64 Cases From A Single Institution
    Estrella, Jeannelyn S.
    Li, Lei
    Rashid, Asif
    Wang, Hua
    Katz, Matthew H.
    Fleming, Jason B.
    Abbruzzese, James L.
    Wang, Huamin
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2014, 38 (02) : 147 - 157
  • [5] Hav Monirath, 2009, Malays J Pathol, V31, P137
  • [6] Analysis of 340 Patients with Solid Pseudopapillary Tumors of the Pancreas: A Closer Look at Patients with Metastatic Disease
    Jutric, Zeljka
    Rozenfeld, Yelena
    Grendar, Jan
    Hammill, Chet W.
    Cassera, Maria A.
    Newell, Pippa H.
    Hansen, Paul D.
    Wolf, Ronald F.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2017, 24 (07) : 2015 - 2022
  • [7] Laparoscopic Resection of Pancreatic Tail Solid Pseudopapillary Tumour in a Young Male
    Kanchana, W. G. P.
    Shaminda, R. A. A.
    Galketiya, K. B.
    Pinto, V.
    Walisinghe, D.
    Wijetunge, S.
    Heendeniya, R.
    [J]. CASE REPORTS IN GASTROINTESTINAL MEDICINE, 2016, 2016
  • [8] Predicting Recurrence of Pancreatic Solid Pseudopapillary Tumors After Surgical Resection A Multicenter Analysis in Korea
    Kang, Chang Moo
    Choi, Sung Hoon
    Kim, Song Cheol
    Lee, Woo Jung
    Choi, Dong Wook
    Kim, Sun Whe
    [J]. ANNALS OF SURGERY, 2014, 260 (02) : 348 - 355
  • [9] Solid Pseudopapillary Tumors of the Pancreas: Specific Pathological Features Predict the Likelihood of Postoperative Recurrence
    Marchegiani, Giovanni
    Andrianello, Stefano
    Massignani, Marta
    Malleo, Giuseppe
    Maggino, Laura
    Paiella, Salvatore
    Ferrone, Cristina R.
    Luchini, Claudio
    Scarpa, Aldo
    Capelli, Paola
    Mino-Kenudson, Mari
    Lillemoe, Keith D.
    Bassi, Claudio
    Fernandez-Del Castillo, Carlos
    Salvia, Roberto
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2016, 114 (05) : 597 - 601
  • [10] Primary clear cell ductal adenocarcinoma of the pancreas: A case report and clinicopathologic literature review
    Modi, Yashpal
    Shaaban, Hamid
    Gauchan, Dron
    Maroules, Michael
    Parikh, Nalini
    Guron, Gunwant
    [J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2014, 10 (03) : 773 - 776