Roles of Inflammasomes in Inflammatory Kidney Diseases

被引：43

作者：

Fan, Jinjin ^{[1
]}

Xie, Kaifeng ^{[2
]}

Wang, Liqin ^{[3
]}

Zheng, Nuoyan ^{[4
]}

Yu, Xueqing ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510000, Guangdong, Peoples R China

[2] Guangdong Med Univ, Zhanjiang 524001, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou 510000, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Translat Med Ctr, Guangzhou 510000, Guangdong, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2019年 / 2019卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; INHIBITING NLRP3 INFLAMMASOME; ATTENUATES MURINE LUPUS; INNATE IMMUNE DETECTION; SMOOTH-MUSCLE-CELLS; RENAL INFLAMMATION; MECHANISTIC INSIGHTS; RHEUMATOID-ARTHRITIS; DIABETIC-NEPHROPATHY; RECEPTOR ANTAGONIST;

D O I：

10.1155/2019/2923072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The immune system has a central role in eliminating detrimental factors, by frequently launching inflammatory responses towards pathogen infection and inner danger signal outbreak. Acute and chronic inflammatory responses are critical determinants for consequences of kidney diseases, in which inflammasomes were inevitably involved. Inflammasomes are closely linked to many kidney diseases such as acute kidney injury and chronic kidney diseases. Inflammasomes are macromolecules consisting of multiple proteins, and their formation initiates the cleavage of procaspase-1, resulting in the activation of gasdermin D as well as the maturation and release of interleukin-1 beta and IL-18, leading to pyroptosis. Here, we discuss the mechanism in which inflammasomes occur, as well as their roles in inflammatory kidney diseases, in order to shed light for discovering new therapeutical targets for the prevention and treatment of inflammatory kidney diseases and consequent end-stage renal disease.

引用

页数：14

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