Underestimated Potential of Organometallic Rhenium Complexes as Anticancer Agents

被引：249

作者：

Leonidova, Anna ^{[1
]}

Gasser, Gilles ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

来源：

ACS CHEMICAL BIOLOGY | 2014年 / 9卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

ONE-POT SYNTHESIS; CORRELATING FLUORESCENCE; TRICARBONYL COMPLEXES; CARBONIC-ANHYDRASES; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE; TC-99M COMPLEXES; ISOSTRUCTURAL RE; TECHNETIUM; BEHAVIOR;

D O I：

10.1021/cb500528c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the recent years, organometallic compounds have become recognized as promising anti-cancer drug candidates. While radioactive Re-186/188 compounds are already used in clinics for cancer treatment, cold Re organometallic compounds have mostly been explored as luminescent probes for cell imaging and photosensitizers in photocatalysis. However, a growing number of studies have recently revealed the potential of Re organometallic complexes as anti-cancer agents. Several compounds have displayed cytotoxicity equaling or exceeding that of the well-established anti-cancer drug cisplatin. In this review, we present the currently known Re organometallic complexes that have shown anti-proliferative activity on cancer cell lines. A particular emphasis is placed on their cellular uptake and localization as well as their potential mechanism of action.

引用

页码：2180 / 2193

页数：14

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