Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors

被引：14

作者：

Kamal, A. ^{[1
]}

Satyanarayana, M.

Devaiah, V.

Rohini, V.

Yadav, J. S.

Mullick, B.

Nagaraja, V.

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 07期

关键词：

coumarins; phthalimides; naphthalimides and fluoroquinolone DNA gyrase inhibition;

D O I：

10.2174/157018006778194862

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.

引用

页码：494 / 502

页数：9

共 49 条

[31] Design, Synthesis, and In Silico Studies of 1,2,3-Triazole-Linked Coumarin-Chalcone Hybrids as Potential Antifungal Agents [J].

Kavita, Kavita ;

Kumar, Sumit ;

Maikhuri, Vipin K. ;

Deo, Gautam ;

Tiwari, Mrityunjay K. ;

Maity, Jyotirmoy ;

Singh, Brajendra K. .

SYNLETT, 2025,

[32] Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies [J].

Garcia, Santiago ;

Mercado-Sanchez, Itzel ;

Bahena, Luis ;

Alcaraz, Yolanda ;

Garcia-Revilla, Marco A. ;

Robles, Juvencio ;

Santos-Martinez, Nancy ;

Ordaz-Rosado, David ;

Garcia-Becerra, Rocio ;

Vazquez, Miguel A. .

MOLECULES, 2020, 25 (21)

[33] Synthesis and Biological Evaluation of 3-thiazolocoumarinyl Schiff-base Derivatives as Cholinesterase Inhibitors [J].

Raza, Rabia ;

Saeed, Aamer ;

Arif, Mubeen ;

Mahmood, Shamsul ;

Muddassar, Muhammad ;

Raza, Ahsan ;

Iqbal, Jamshed .

CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 80 (04) :605-615

[34] Synthesis, docking study, and biological evaluation of novel umbellipherone/hymecromone derivatives as acetylcholinesterase/butyrylcholinesterase inhibitors [J].

Moradi, Alireza ;

Faraji, Laleh ;

Nadri, Hamid ;

Hasanpour, Zeinab ;

Moghadam, Farshad H. ;

Pakseresht, Bahar ;

Golshani, Mostafa ;

Moghimi, Setareh ;

Ramazani, Ali ;

Firoozpour, Loghman ;

Khoobi, Mehdi ;

Foroumadi, Alireza .

MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (07) :1741-1747

[35] Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors [J].

Dasko, Mateusz ;

Przybylowska, Maja ;

Rachon, Janusz ;

Maslyk, Maciej ;

Kubinski, Konrad ;

Misiak, Majus ;

Skladanowski, Andrzej ;

Demkowicz, Sebastian .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 128 :79-87

[36] Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives [J].

Montanari, Serena ;

Bartolini, Manuela ;

Neviani, Paolo ;

Belluti, Federica ;

Gobbi, Silvia ;

Pruccoli, Letizia ;

Tarozzi, Andrea ;

Falchi, Federico ;

Andrisano, Vincenza ;

Miszta, Przemyslaw ;

Cavalli, Andrea ;

Filipek, Slawomir ;

Bisi, Alessandra ;

Rampa, Angela .

CHEMMEDCHEM, 2016, 11 (12) :1296-1308

[37] Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents [J].

Jun, Maria ;

Bacay, Alyssa F. ;

Moyer, James ;

Webb, Andrew ;

Carrico-Moniz, Dora .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (19) :4654-4658

[38] Design, synthesis and biological evaluation of novel benzocoumarin derivatives as potent inhibitors of MAO-B activity [J].

Meletli, Furkan ;

Gunduz, Cihan ;

Alparslan, Mustafa Muhlis ;

Attar, Azade ;

Demir, Serap ;

Iskit, Ece ;

Danis, Ozkan .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 113

[39] New Biscoumarin Derivatives as Potent α-Glucosidase Inhibitors: Synthesis, Biological Evaluation, Kinetic Analysis, and Docking Study [J].

Mohammadi-Khanaposhtani, Maryam ;

Yahyavi, Hoda ;

Barzegaric, Ebrahim ;

Imanparast, Somaye ;

Heravi, Majid M. ;

Faramarzi, Mohammad Ali ;

Foroumadi, Alireza ;

Adibi, Hossein ;

Larijani, Bagher ;

Mandavi, Mohammad .

POLYCYCLIC AROMATIC COMPOUNDS, 2020, 40 (04) :915-926

[40] Synthesis and Biological Evaluation of 4-Sulfamoylphenyl/Sulfocoumarin Carboxamides as Selective Inhibitors of Carbonic Anhydrase Isoforms hCAII, IX, and XII [J].

Angapelly, Srinivas ;

Angeli, Andrea ;

Khan, Arbaj Jabbar ;

Ramya, P. V. Sri ;

Supuran, Claudiu T. ;

Arifuddin, Mohammed .

CHEMMEDCHEM, 2018, 13 (12) :1165-1171

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