Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors

被引：14
作者：
Kamal, A. [1 ]
Satyanarayana, M.
Devaiah, V.
Rohini, V.
Yadav, J. S.
Mullick, B.
Nagaraja, V.
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 07期
关键词：
coumarins; phthalimides; naphthalimides and fluoroquinolone DNA gyrase inhibition;
D O I：
10.2174/157018006778194862
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
引用
收藏
页码：494 / 502
页数：9
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