Synthesis and biological evaluation of coumarin linked fluoroquinolones, phthalimides and naphthalimides as potential DNA gyrase inhibitors

被引：14
作者：
Kamal, A. [1 ]
Satyanarayana, M.
Devaiah, V.
Rohini, V.
Yadav, J. S.
Mullick, B.
Nagaraja, V.
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2006年 / 3卷 / 07期
关键词：
coumarins; phthalimides; naphthalimides and fluoroquinolone DNA gyrase inhibition;
D O I：
10.2174/157018006778194862
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
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收藏
页码：494 / 502
页数：9
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[1]   New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation [J].
Swain, Baijayantimala ;
Angeli, Andrea ;
Singh, Priti ;
Supuran, Claudiu T. ;
Arifuddin, Mohammed .
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (15)
[2]   Synthesis, biological evaluation, and molecular dynamics of novel coumarin based phosphorothioates as cholinesterase inhibitors [J].
El-Hussieny, Marwa ;
ElMansy, Mohamed F. ;
Ewies, Ewies F. ;
El-Rashedy, Ahmed A. ;
Ibrahim, Abeer Y. ;
El-Sayed, Naglaa F. .
JOURNAL OF MOLECULAR STRUCTURE, 2023, 1272
[3]   Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors [J].
Thacker, Pavitra S. ;
Angeli, Andrea ;
Argulwar, Omkar S. ;
Tiwari, Prerna L. ;
Arifuddin, Mohammed ;
Supuran, Claudiu T. .
BIOORGANIC CHEMISTRY, 2020, 98
[4]   Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases [J].
Valente, Sergio ;
Bana, Emilie ;
Viry, Elodie ;
Bagrel, Denyse ;
Kirsch, Gilbert .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (19) :5827-5830
[5]   Design, Synthesis and Biological Evaluation of Some New Coumarin Derivatives as Potential Antimicrobial Agents [J].
Singh, Lav Kumar ;
Priyanka ;
Singh, Vineeta ;
Katiyar, Diksha .
MEDICINAL CHEMISTRY, 2015, 11 (02) :128-134
[6]   DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents [J].
Khan, Tabassum ;
Sankhe, Kaksha ;
Suvarna, Vasanti ;
Sherje, Atul ;
Patel, Kavitkumar ;
Dravyakar, Bhushan .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 103 :923-938
[7]   Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents [J].
Bach, Duc-Hiep ;
Liu, Jian-Yu ;
Kim, Won Kyung ;
Hong, Ji-Young ;
Park, So Hyun ;
Kim, Donghwa ;
Qin, Si-Ning ;
Luu, Thi-Thu-Trang ;
Park, Hyen Joo ;
Xu, Yong-Nan ;
Lee, Sang Kook .
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (13) :3396-3405
[8]   Synthesis and evaluation of coumarin/piperazine hybrids as acetylcholinesterase inhibitors [J].
Zhang, Juan ;
Jiang, Cheng-Shi .
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (06) :1717-1727
[9]   Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors [J].
Thacker, Pavitra S. ;
Alvala, Mallika ;
Arifuddin, Mohammed ;
Angeli, Andrea ;
Supuran, Claudiu T. .
BIOORGANIC CHEMISTRY, 2019, 86 :386-392
[10]   Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite [J].
Singh, Anil K. ;
Rajendran, Vinoth ;
Pant, Akansha ;
Ghosh, Prahlad C. ;
Singh, Neelu ;
Latha, N. ;
Garg, Sandeep ;
Pandey, Kailash C. ;
Singh, Brajendra K. ;
Rathi, Brijesh .
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (08) :1817-1827
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