Allergen-specific immunotherapy: A unique model of tolerance induction in humans

被引：1

作者：

Botturi, K. ^{[1
,2
,3
]}

Pipet, A. ^{[1
,2
,3
]}

Birnbaum, J. ^{[4
,5
]}

Lacoeuille, Y. ^{[1
,2
,3
]}

Vervloet, D. ^{[4
,5
]}

Magnan, A. ^{[1
,2
,3
]}

机构：

[1] Hop G & R Laennec, Inst Thorax, Serv Pneumol, F-44093 Nantes 1, France

[2] Univ Nantes, Fac Med, F-44000 Nantes, France

[3] CHU Nantes, Inst Thorax, Serv Pneumol, F-44000 Nantes, France

[4] Univ Aix Marseille 2, Fac Med, F-13005 Marseille, France

[5] Assistance Publ Hop Marseille, Serv Pneumoallergol, F-13005 Marseille, France

来源：

REVUE FRANCAISE D ALLERGOLOGIE | 2009年 / 49卷 / 03期

关键词：

Allergen immunotherapy; Allergic rhinitis; Asthma; Pollen; House dust mite; Hymenoptera venom; GRASS-POLLEN IMMUNOTHERAPY; MESSENGER-RNA EXPRESSION; T-CELL-ACTIVATION; NASAL-MUCOSA; INTERFERON-GAMMA; RESPONSES; IMMUNITY; IL-10; DESENSITIZATION; INTERLEUKIN-4;

D O I：

10.1016/j.reval.2009.01.014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Appearing at the beginning of the XXth century, allergen-specific immunotherapy (SIT) has long been used in the treatment of allergic rhinitis and asthma and in allergy to hymenoptera venom without precise knowledge of its mechanisms of action. However, the development of modem immunological tools brought important insights into these mechanisms allowing consideration of new strategies for SIT. It is currently understood that SIT modifies the immune response to allergens by reorientating the inflammatory reaction towards Th1 and T-regulatory pathways with induction of IFN-gamma and IL-10. This action is exerted both at the adaptive (T-cell) and at the innate (allergen-presenting cell) levels of immunity. (c) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：206 / 210

页数：5

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