Symptomatic thrombosis in Turkish neonates

Objective: To investigate the association of two common prothrombotic mutations, factor V G 169 1 A (FV G 169 1 A) and prothrombin G20210A (PT G20210A), in neonates with thrombosis. Methods: Twenty-six neonates with thrombosis were assessed with the spectrum of assays for thrombophilia, including the two DNA-based prothrombotic factors. Results: Eight patients (31%) had the FV G 169 1 A mutation in heterozygous state. PT G20210A Mutation was detected in four patients (15%). Overall, two common prothrombotic factors were detected in 12 neonates (46%) and an underlying disease or a triggering event in IS neonates (69%). Thrombosis was considered to be idiopathic in five neonates (19%). Conclusions: The pathogenesis of thrombosis in neonates is multifactorial. Along with underlying diseases or triggering events, congenital prothrombotic factors (FV G1691A and PT G20210A) showed a trend toward a higher frequency in neonates with thrombosis. These data indicate that Mutations associated with underlying disorders in neonates may contribute to the development of thromboembolic disease.