Apoptosis in young and old denervated rat skeletal muscle

被引：27

作者：

Lee, Gangpyo ^{[1
]}

Lim, Jae-Young ^{[1
]}

Frontera, Walter R. ^{[2
,3
]}

机构：

[1] Seoul Natl Univ, Dept Rehabil Med, Seoul Natl Univ Bundang Hosp, Coll Med, 82 Gumi Ro 173, Seongnam Si 13620, Gyeonggi Do, South Korea

[2] Vanderbilt Univ, Med Ctr, Dept Phys Med & Rehabil, Nashville, TN USA

[3] Univ Puerto Rico, Dept Physiol, Sch Med, San Juan, PR 00936 USA

来源：

MUSCLE & NERVE | 2017年 / 55卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

aging; apoptosis; denervation; muscle atrophy; rat; skeletal muscle; LONG-TERM DENERVATION; HINDLIMB MUSCLES; SOLEUS MUSCLE; AGE; SARCOPENIA; DISUSE; SLOW; NECROSIS; ATROPHY; CONTRACTILITY;

D O I：

10.1002/mus.25221

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We investigated the apoptotic response to different degrees of denervation in young and older rats randomized into control (C), partial (PD), and complete denervation (CD) of muscles innervated by the sciatic nerve. Methods: Muscle wet weight to body weight (MWW/BW), myosin heavy chain (MHC) isoforms, and fiber cross-sectional area were determined in gastrocnemius and soleus muscles. Apoptotic responses were determined by changes in myonuclei and expression of Bcl-2 and BAX. Results: PD and CD resulted in significant reductions in MWW/BW and FCSA in both young and older rats. Older controls had greater apoptotic responses than young controls. Apoptotic responses were greater in PD and CD than in C in both age groups. No statistical interaction between denervation and age group was seen. Conclusions: Older age was associated with increased level of apoptosis, but older muscle was not more vulnerable to the effect of denervation. Muscle Nerve55: 262-269, 2017

引用

页码：262 / 269

页数：8

共 53 条

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