Annexin A7 Levels Increase in Rats With Traumatic Brain Injury and Promote Secondary Brain Injury

被引：12

作者：

Gao, Fan ^{[1
]}

Li, Di ^{[2
,3
]}

Rui, Qin ^{[4
]}

Ni, Haibo ^{[2
]}

Liu, Huixiang ^{[2
]}

Jiang, Feng ^{[2
]}

Tao, Li ^{[5
]}

Gao, Rong ^{[2
]}

Dang, Baoqi ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Zhangjiagang Hosp Tradit Chinese Med, Dept Rehabil, Suzhou, Peoples R China

[2] First Peoples Hosp Zhangjiagang, Dept Neurosurg, Suzhou, Peoples R China

[3] First Peoples Hosp Zhangjiagang, Translat Med Ctr, Suzhou, Peoples R China

[4] First Peoples Hosp Zhangjiagang, Clin Lab, Suzhou, Peoples R China

[5] First Peoples Hosp Zhangjiagang, Dept Pharm, Suzhou, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2018年 / 12卷

关键词：

AnnexinA7; traumatic brain injury; secondary brain injury; neuron apoptosis; rat models; EXCITOTOXICITY; FAMILY;

D O I：

10.3389/fnins.2018.00357

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The incidence of traumatic brain injury (TBI) has been increasing annually. Annexin A7 is a calcium-dependent phospholipid binding protein. It can promote melting of the cell membrane. Recent studies have shown that it plays an important role in atherosclerosis, other cardiovascular diseases, and a variety of tumors. However, few studies of ANXA7 in TBI have been performed. We here observed how ANXA7 changes after TBI and discuss whether brain injury is associated with the use of ANXA7 antagonist intervention. Experimental Results: 1. After TBI, ANXA7 levels were higher than in the sham group, peaking 24 h after TBI. 2. The use of siA7 was found to reduce the expression of A7 in the injured brain tissue, and also brain edema, BBB damage, cell death, and apoptosis relative to the sham group. Conclusion : ANXA7 promotes the development of secondary brain injury (SBI) after TBI.

引用

页数：8

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