Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons

被引：126

作者：

Rolls, MM

Hall, DH

Victor, M

Stelzer, EHK

Rapoport, TA ^{[1
]}

机构：

[1] Harvard Univ, Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Med Sch, Dept Pathol, Boston, MA 02115 USA

[3] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Ctr C Elegans Anat, Bronx, NY 10461 USA

[4] European Mol Biol Lab, Light Microscopy Grp, D-69117 Heidelberg, Germany

[5] European Mol Biol Lab, Cell Biophys Programme, D-69117 Heidelberg, Germany

来源：

MOLECULAR BIOLOGY OF THE CELL | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1091/mbc.01-10-0514

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum (ER) is divided into rough and smooth domains (RER and SER). The two domains share most proteins, but RER is enriched in some membrane proteins by an unknown mechanism. We studied RER protein targeting by expressing fluorescent protein fusions to ER membrane proteins in Caenorhabditis elegans. In several cell types RER and general ER proteins colocalized, but in neurons RER proteins were concentrated in the cell body, whereas general ER proteins were also found in neurites. Surprisingly RER membrane proteins diffused rapidly within the cell body, indicating they are not localized by immobilization. Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting RER membrane proteins.

引用

页码：1778 / 1791

页数：14

共 51 条

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